Ignite Creation Date:
2024-05-06 @ 4:31 PM
Last Modification Date:
2024-10-26 @ 2:11 PM
Study NCT ID:
NCT05014516
Status:
TERMINATED
Last Update Posted:
2024-04-17
First Post:
2021-07-30
Brief Title:
Lung Structure-Function In SurVivors of Mild and SEvere COVID-19 Infection 129Xe MRI
Sponsor:
The Hospital for Sick Children
Organization:
The Hospital for Sick Children
Study Overview
Official Title:
Lung Structure-Function In SurVivors of Mild and SEvere COVID-19 Infection 129Xe MRI For Rapid Evaluation and NExt-wave Healthcare Planning
Status:
TERMINATED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Recruitment Challenges
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LivCovidFree
Brief Summary:
In this study the Investigators aim to deploy UTE and HP 129Xe MRI for structural and functional evaluation of persistent lung abnormalities in COVID-19 survivors
Detailed Description:
What is COVID-19 The ongoing Coronavirus Disease 2019 COVID-19 pandemic is caused when an individual is infected with the SARS-CoV-2 virus This infection can result in pneumonia involving the small airways and alveoli the tiny air sacs at the end of the airways that help oxygen get into the blood COVID-19 can cause damage to the lungs making it hard to breathe without medical help To understand what is happening to a patients lungs doctors may use imaging tests such as chest x-rays or CT Scans computed tomography However these types of tests may not tell the Investigators the whole story
What is the purpose of the study Led by The Hospital for Sick Children SickKids this study is being done to determine if MRI magnetic resonance imaging scans can tell the Investigators more about the lungs of people who had COVID-19 The Investigators will use a special type of MRI where participants breathe in a special gas hyperpolarized xenon-129 before they have the MRI This gas will help the Investigators to see the lungs The advantage of MRI scans is that there is no radiation involved in these types of images
What is involved In this study participants will have an MRI of their lungs The Investigators will examine these MRI scans to see if the Investigators can identify any changes in the structure or the function of the lung If the Investigators do find any changes they will see how these changes relate to other tests that have been conducted or other parts of the clinical story
The participants will be asked to come to SickKids for 3 study visits A fourth visit will be conducted via telephone These visits will span over 3 years Each study visit will take about 4 hours If the participant is unable to attend one of the in-person visits they will be given the option for a phonevirtual visit instead
What is the purpose of the study Led by The Hospital for Sick Children SickKids this study is being done to determine if MRI magnetic resonance imaging scans can tell the Investigators more about the lungs of people who had COVID-19 The Investigators will use a special type of MRI where participants breathe in a special gas hyperpolarized xenon-129 before they have the MRI This gas will help the Investigators to see the lungs The advantage of MRI scans is that there is no radiation involved in these types of images
What is involved In this study participants will have an MRI of their lungs The Investigators will examine these MRI scans to see if the Investigators can identify any changes in the structure or the function of the lung If the Investigators do find any changes they will see how these changes relate to other tests that have been conducted or other parts of the clinical story
The participants will be asked to come to SickKids for 3 study visits A fourth visit will be conducted via telephone These visits will span over 3 years Each study visit will take about 4 hours If the participant is unable to attend one of the in-person visits they will be given the option for a phonevirtual visit instead
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None