Ignite Creation Date:
2024-05-06 @ 4:31 PM
Last Modification Date:
2024-10-26 @ 2:11 PM
Study NCT ID:
NCT05014464
Status:
RECRUITING
Last Update Posted:
2024-05-31
First Post:
2021-08-14
Brief Title:
ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma
Sponsor:
Hunan Province Tumor Hospital
Organization:
Hunan Province Tumor Hospital
Study Overview
Official Title:
Molecular Characterization and Clinical Outcomes of ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ATPase
Brief Summary:
This study was to explore the efficacy of ALK-TKI in lung squamous cell carcinoma Approximately 5 of lung adenocarcinomas have oncogenic fusions of EML-4 and ALK a mutation associated with tumorigenesis and migration
Detailed Description:
This research focuses on exploring epidemiology distributions and the efficacy and prognosis of ALK-TKI in lung squamous cell carcinomaApproximately 5 of lung adenocarcinomas have oncogenic fusions of EML-4 and ALK a mutation associated with tumorigenesis and migration Several studies have shown that in patients with ALK-rearranged non-small cells the use of ALK inhibitors can achieve better efficacy and significantly prolong overall survival However few of them performed Fish or NGS tests Our data demonstrates that lung squamous cell carcinoma with ALK rearrangement responds well to ALK-TKI and correspondingly has a significant improvement in survival time and prognosis providing a basis for the treatment of ALK-positive patients with lung squamous cell carcinoma At the same time we believe that genetic testing is also required for lung squamous cell carcinoma to achieve more accurate medication
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None