Ignite Creation Date:
2024-05-05 @ 5:26 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00457769
Status:
UNKNOWN
Last Update Posted:
2021-02-17
First Post:
2007-04-05
Brief Title:
Aricept to Improve Functional Tasks in Vascular Dementia
Sponsor:
Kessler Foundation
Organization:
Kessler Foundation
Study Overview
Official Title:
Phase 1 Study of Aricept Plus a Behavioral Strategy to Improve Functional Tasks in Vascular Dementia
Status:
UNKNOWN
Status Verified Date:
2021-02
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Medications for memory improvement are available but they may not actually improve the ability to do real world tasks The purpose of this research study is to determine if a medicine used to treat memory problems donepezilAricept enhances the ability to remember steps of functional tasks and the actual ability to perform tasks relevant to real-life independence Aricept is an FDA approved medication for the treatment of Alzheimers disease Aricept is an investigational drug for the purposes of this study and is not approved for this purpose
Detailed Description:
All participants will receive a behavioral intervention as part of the testing protocol they will be asked to generate words to complete a phrase as they read written steps to perform functional tasks Mood will be assessed using the Geriatric Depression Scalesee page 8 Participants will be asked to estimate their memory immediate attention mood functional tasks performing cooking and financial task and ability to take medications correctly pre-test or offline ratings abstract judgments of their own ability not based directly on performance They will perform self-assessments of their cognitive functional abilities and mood using Likert scales They will mark each of 5 vertical 235 cm lines centered on white paper to indicate their ability Each line will be labeled for each domain
To estimate of naming ability show the subject the Likert Scale attached for the naming domain Then explain This scale is to measure how well you think your ability to name Here is the top where you will mark if you think your performance is perfect here is the bottom if you think you are terrible You may be somewhere in between broadly indicated the whole middle area mark where you think your performance would belong on this scale
This standard protocol will be used by the examiner in this study to explain each domain with specific types of tasks and give subjects practical hypothetical examples of good and poor performance
Ability to take medication Functional memory as applied to medication compliance will be assessed with the Hopkins Medication Schedule HMS This test has two part HMS and pill box The test will serve as a good evaluation of subjects functional memory which we suspect it will be most strongly affected by Anosognosia
The HMS the participant was read and read along with a hypothetical scenario in which her physician gave her 1 prescription for an antibiotic and for aspirin to treat an infection along with directions for taking each The participant was then asked to plan a schedule for taking these medications and water during the course of a day following the instructions provided
To estimate of naming ability show the subject the Likert Scale attached for the naming domain Then explain This scale is to measure how well you think your ability to name Here is the top where you will mark if you think your performance is perfect here is the bottom if you think you are terrible You may be somewhere in between broadly indicated the whole middle area mark where you think your performance would belong on this scale
This standard protocol will be used by the examiner in this study to explain each domain with specific types of tasks and give subjects practical hypothetical examples of good and poor performance
Ability to take medication Functional memory as applied to medication compliance will be assessed with the Hopkins Medication Schedule HMS This test has two part HMS and pill box The test will serve as a good evaluation of subjects functional memory which we suspect it will be most strongly affected by Anosognosia
The HMS the participant was read and read along with a hypothetical scenario in which her physician gave her 1 prescription for an antibiotic and for aspirin to treat an infection along with directions for taking each The participant was then asked to plan a schedule for taking these medications and water during the course of a day following the instructions provided
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None