Ignite Creation Date:
2024-05-05 @ 5:26 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00452231
Status:
UNKNOWN
Last Update Posted:
2007-03-27
First Post:
2007-03-26
Brief Title:
RCT of CBT Combined With D-Cycloserine for Treating PTSD
Sponsor:
Université de Montréal
Organization:
Université de Montréal
Study Overview
Official Title:
Comparative Study of the Efficacy of a Cognitive-Behavioral Therapy for Post-Traumatic Stress Disorder With or Without D-Cycloserine
Status:
UNKNOWN
Status Verified Date:
2007-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate if the effectiveness of cognitive-behavioral therapy for post-traumatic stress disorder can be increased by combining it with D-cycloserine TCCD-cycloserine by comparing with a placebo TCCplacebo
Detailed Description:
Post-traumatic stress disorder PTSD is one of the most frequent anxiety disorder in the general population Kessler and al 2005 Currently the treatment of choice for PTSD is cognitive-behavioral therapy CBT Foa Davidson and Frances 1999 Based on remission rates after treatment successful outcomes of CBT for PTSD vary between 46 and 54 when dropouts are considered and between 56 and 70 among those who completed their therapy Bradley and al 2005 Thus there is room for improvement
Recently the results of two published studies on the treatment of phobia of heights Ressler and al 2004 and social phobia Hofman 2006 indicated that the efficacy of CBT was increased by adding D-cycloserine The superior efficacy of CBTD-cycloserine over CBTPlacebo in the treatment of anxiety disorders can result from a greater release of glutamate a substance facilitating the extinction of fear Davis Myers Ressler and Rothbaum 2005 Richardson Ledgerwood an Cranney 2004 However to our knowledge no study has yet compared CBTD-cycloserine to CBTPlacebo in the treatment of PTSD The main hypothesis of the current study is that the efficacy of CBT for PTSD will be increased when combined with D-cycloserine compared to a placebo
Recently the results of two published studies on the treatment of phobia of heights Ressler and al 2004 and social phobia Hofman 2006 indicated that the efficacy of CBT was increased by adding D-cycloserine The superior efficacy of CBTD-cycloserine over CBTPlacebo in the treatment of anxiety disorders can result from a greater release of glutamate a substance facilitating the extinction of fear Davis Myers Ressler and Rothbaum 2005 Richardson Ledgerwood an Cranney 2004 However to our knowledge no study has yet compared CBTD-cycloserine to CBTPlacebo in the treatment of PTSD The main hypothesis of the current study is that the efficacy of CBT for PTSD will be increased when combined with D-cycloserine compared to a placebo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None