Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005695
Status:
COMPLETED
Last Update Posted:
2015-12-23
First Post:
2000-05-25
Brief Title:
Physical Training and Blood Pressure in High Risk Youths
Sponsor:
Augusta University
Organization:
Augusta University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2002-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the effects of physical activity on blood pressure and body fat in children varying in ethnicity gender and health status
Detailed Description:
DESIGN NARRATIVE
There were two specific aims The first was to test the hypothesis that controlled physical training PT reduced blood pressure at rest and in reaction to forehead cold and exercise stressors in 8-9 year olds who were high in both blood pressure and body fatness Subjects were divided equally on gender and blood pressure and body fatness Subjects were divided equally on gender and ethnicity blackwhite Both resting and reactive blood pressure were correlated with left ventricular mass and were predictive of future essential hypertension The underlying hemodynamic regulators of blood pressure cardiac output and the total peripheral resistance were measured with impedance cardiography to explore hemodynamic mechanisms through which training had a favorable influence on blood pressure and left ventricular mass
The second aim tested the hypothesis that physical training reduced percent body fat as measured with dual energy x-ray absorptiometry DEXA Children above the 70th percentile in both blood pressure and fatness were randomly assigned within ethnicity and gender to a physical training or waiting list control group After the physical training group underwent four months of training all subjects were retested and these data were used to test the primary hypotheses The initial control subjects then performed four months of physical training after which they were retested The data from this second phase were added to the data of the initial physical training group to explore interactions of training with gender and ethnicity The initial physical training group was brought back four months after cessation of training to see if the changes elicited by the training were reversible To document the stimulation provided by the training heart rate was monitored during training sessions To observe the time course of changes between the full lab testing sessions skinfolds and resting blood pressure were measured monthly Diet and free living physical activity were assessed to help explain changes in body composition Aerobic fitness was measured with treadmill tests of maximal oxygen consumption
There were two specific aims The first was to test the hypothesis that controlled physical training PT reduced blood pressure at rest and in reaction to forehead cold and exercise stressors in 8-9 year olds who were high in both blood pressure and body fatness Subjects were divided equally on gender and blood pressure and body fatness Subjects were divided equally on gender and ethnicity blackwhite Both resting and reactive blood pressure were correlated with left ventricular mass and were predictive of future essential hypertension The underlying hemodynamic regulators of blood pressure cardiac output and the total peripheral resistance were measured with impedance cardiography to explore hemodynamic mechanisms through which training had a favorable influence on blood pressure and left ventricular mass
The second aim tested the hypothesis that physical training reduced percent body fat as measured with dual energy x-ray absorptiometry DEXA Children above the 70th percentile in both blood pressure and fatness were randomly assigned within ethnicity and gender to a physical training or waiting list control group After the physical training group underwent four months of training all subjects were retested and these data were used to test the primary hypotheses The initial control subjects then performed four months of physical training after which they were retested The data from this second phase were added to the data of the initial physical training group to explore interactions of training with gender and ethnicity The initial physical training group was brought back four months after cessation of training to see if the changes elicited by the training were reversible To document the stimulation provided by the training heart rate was monitored during training sessions To observe the time course of changes between the full lab testing sessions skinfolds and resting blood pressure were measured monthly Diet and free living physical activity were assessed to help explain changes in body composition Aerobic fitness was measured with treadmill tests of maximal oxygen consumption
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL049549 | NIH | None | httpsreporternihgovquickSearchR01HL049549 |