Ignite Creation Date:
2024-05-06 @ 4:27 PM
Last Modification Date:
2024-10-26 @ 2:10 PM
Study NCT ID:
NCT04995354
Status:
UNKNOWN
Last Update Posted:
2021-08-06
First Post:
2021-07-29
Brief Title:
Efficacy of EGF-loaded Self Healing Gel in Treatment of Oral Mucositis
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Self Healing Gel as a Vehicle for Recombinant Human Epidermal Growth Factor in Treatment of Oral Mucositis Following Cancer Therapy
Status:
UNKNOWN
Status Verified Date:
2021-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cancer treatment including radiation along with aggressive chemotherapy increases the patients survival rate However they possess toxic side effects Oral mucositis is one of the most serious complications of cancer treatment which occurs in most of patients receiving cancer therapy Mucositis can dramatically affect the patients quality of life Epidermal growth factor EGF is a dominant factor in early keratinocyte differentiation proliferation and migration However a major obstacle in most studies is that there isnt prolonged contact between the applied treatment and the oral mucosa to achieve the optimum therapeutic effect Thus a new vehicle for EGF is needed to achieve sufficient prolonged contact with oral mucosa The present project aims at employing EGF as therapeutic agent for mucositis dealing with the challenges of delivery of such macromolecule to the oral mucosa by using self-healing gels to maximize the drug effect
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None