Ignite Creation Date:
2024-05-06 @ 4:27 PM
Last Modification Date:
2024-10-26 @ 2:10 PM
Study NCT ID:
NCT04986150
Status:
UNKNOWN
Last Update Posted:
2021-10-27
First Post:
2021-06-30
Brief Title:
Sex Differences in Muscle Damage Following Resistance Exercise With or Without Milk Protein Ingestion
Sponsor:
Durham University
Organization:
Durham University
Study Overview
Official Title:
Sex Differences in Resistance Exercise-induced Muscle Damage The Impact of Milk Protein Ingestion
Status:
UNKNOWN
Status Verified Date:
2021-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EIMD-MILK
Brief Summary:
Purpose To investigate the impact of milk protein ingestion on resistance exercise-induced muscle damage in untrained males and females
Rationale Unaccustomed resistance exercise can cause muscle damage presenting as muscle soreness and reduced muscle function - such as loss of strength power and flexibility - for several days after the exercise bout Therefore individuals may require longer recovery periods before performing another exercise bout and their performance may be impaired Further muscle soreness may reduce exercise compliance particularly in novice individuals Over time this may compromise the gains in muscle mass and strength achieved through exercise training Therefore strategies to reduce the severity of exercise-induced muscle damage andor to enhance post-exercise recovery processes are advantageous for exercising individuals
One such strategy is the consumption of dietary protein before or after muscle-damaging exercise which has shown to alleviate muscle soreness improve blood markers of muscle damage and reduce the decline in maximal force and flexibility In particular consuming 20-gram doses of milk protein in the days after resistance exercise can improve the recovery time of muscle soreness and maximum force and also lower levels of damage markers in the blood However most studies have been conducted with male participants who are well-trained in resistance exercise It has been suggested that males and females respond differently to muscle damage and therefore this research aims to provide a sex comparison in the muscle damage response to an acute bout of resistance exercise with or without milk protein feeding
Therefore 40 healthy young 18-35 years adults 20 males 20 females will be recruited to participate in this randomised controlled trial Maximal leg strength and body composition by dual-energy X-ray absorptiometry DXA will be conducted at baseline In females all primary outcome measures will be obtained during the late follicular phase of the menstrual cycle Participants will then be randomised to a protein dairy yoghurt or placebo oat-based yoghurt dietary condition
Three weeks later participants will complete a high-intensity resistance exercise session on leg extension and leg curl machines to induce muscle damage Various measures of muscle damage blood biomarkers muscle soreness flexibility and swelling will be obtained before immediately after and 24 48 72 and 168 h after the exercise protocol The maximal strength test will be repeated 72 and 168 h after the exercise Participants will consume the protein or placebo yoghurt 4 times per day every 3-4 hours on the day of the exercise bout and the following 3 days Participants habitual activity and dietary intake will be monitored and controlled throughout the study period
Expected outcome It is expected that the resistance exercise protocol will induce muscle damage which will be attenuated with the ingestion of milk protein It cannot be ascertained whether males and females will have the same responses to the exercise or to protein ingestion
Rationale Unaccustomed resistance exercise can cause muscle damage presenting as muscle soreness and reduced muscle function - such as loss of strength power and flexibility - for several days after the exercise bout Therefore individuals may require longer recovery periods before performing another exercise bout and their performance may be impaired Further muscle soreness may reduce exercise compliance particularly in novice individuals Over time this may compromise the gains in muscle mass and strength achieved through exercise training Therefore strategies to reduce the severity of exercise-induced muscle damage andor to enhance post-exercise recovery processes are advantageous for exercising individuals
One such strategy is the consumption of dietary protein before or after muscle-damaging exercise which has shown to alleviate muscle soreness improve blood markers of muscle damage and reduce the decline in maximal force and flexibility In particular consuming 20-gram doses of milk protein in the days after resistance exercise can improve the recovery time of muscle soreness and maximum force and also lower levels of damage markers in the blood However most studies have been conducted with male participants who are well-trained in resistance exercise It has been suggested that males and females respond differently to muscle damage and therefore this research aims to provide a sex comparison in the muscle damage response to an acute bout of resistance exercise with or without milk protein feeding
Therefore 40 healthy young 18-35 years adults 20 males 20 females will be recruited to participate in this randomised controlled trial Maximal leg strength and body composition by dual-energy X-ray absorptiometry DXA will be conducted at baseline In females all primary outcome measures will be obtained during the late follicular phase of the menstrual cycle Participants will then be randomised to a protein dairy yoghurt or placebo oat-based yoghurt dietary condition
Three weeks later participants will complete a high-intensity resistance exercise session on leg extension and leg curl machines to induce muscle damage Various measures of muscle damage blood biomarkers muscle soreness flexibility and swelling will be obtained before immediately after and 24 48 72 and 168 h after the exercise protocol The maximal strength test will be repeated 72 and 168 h after the exercise Participants will consume the protein or placebo yoghurt 4 times per day every 3-4 hours on the day of the exercise bout and the following 3 days Participants habitual activity and dietary intake will be monitored and controlled throughout the study period
Expected outcome It is expected that the resistance exercise protocol will induce muscle damage which will be attenuated with the ingestion of milk protein It cannot be ascertained whether males and females will have the same responses to the exercise or to protein ingestion
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None