Ignite Creation Date:
2024-05-05 @ 5:26 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00459693
Status:
TERMINATED
Last Update Posted:
2020-09-10
First Post:
2007-04-11
Brief Title:
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using 11CPBR28 in HIV-Seropositive Patients With MCMD
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using 11CPBR28 in HIV-Seropositive Patients With MCMD
Status:
TERMINATED
Status Verified Date:
2014-08-28
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this protocol is to measure a receptor in the brain using positron emission tomography PET that is involved in inflammation
Detailed Description:
The peripheral benzodiazepine receptor PBR is distinct from central benzodiazepine receptors associated with GABAa receptors Although PBR was initially identified in peripheral organs such as kidneys endocrine glands and lungs later studies identified PBR in the central nervous system In normal conditions PBR is expressed in low levels in some neurons and glial cells PBR can be a clinically useful marker to detect neuroinflammation because activated microglial cells in inflammatory areas express much greater levels of PBR than in microglial cells in resting conditions
PBR has been imaged with positron emission tomography PET using 11C1-2-chlorophenyl-N-methylpropyl-3-isoquinoline carboxamide PK11195 However this classical ligand provides low levels of specific signal Recently we developed a new ligand N-acetyl-N-2-methoxybenzyl-2-phenoxy-5-pyridinamine 11CPBR28 which showed much greater specific signal than 11CPK11195 in non-human primates ln the present protocol we plan to perform a kinetic brain imaging study with 11CPBR28 in HlV-seronegative controls HIV-seropositive non-impaired patients and HlV-seropositive patients with minor cognitive motor disorderMCMD Each subject will recieve a brain-dedicated PET scan with 20 mCi11CPBR28
PBR has been imaged with positron emission tomography PET using 11C1-2-chlorophenyl-N-methylpropyl-3-isoquinoline carboxamide PK11195 However this classical ligand provides low levels of specific signal Recently we developed a new ligand N-acetyl-N-2-methoxybenzyl-2-phenoxy-5-pyridinamine 11CPBR28 which showed much greater specific signal than 11CPK11195 in non-human primates ln the present protocol we plan to perform a kinetic brain imaging study with 11CPBR28 in HlV-seronegative controls HIV-seropositive non-impaired patients and HlV-seropositive patients with minor cognitive motor disorderMCMD Each subject will recieve a brain-dedicated PET scan with 20 mCi11CPBR28
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 07-M-0129 | None | None | None |