Ignite Creation Date:
2024-05-05 @ 5:26 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00451373
Status:
UNKNOWN
Last Update Posted:
2007-03-23
First Post:
2007-03-22
Brief Title:
Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF NSARF Study
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2007-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We examine the prognosis and etiology of postoperative acute renal failure
Detailed Description:
Postoperative acute renal failure is a serious complication resulting in a prolonged stay and high mortality Acute renal failure ARF develops in 5 to 30 of patients who undergo surgery and for all causes it is associated with mortality rates of 60-90 Despite advances in supportive care and innovations in renal replacement therapies over the past three decades the mortality rate for these patients remains high In the previous analysis of NSARF National Taiwan University Hospital-Surgical Intense Care Unit- acute renal failure database the mortality rate of acute renal failure patients in SICU is 664 dialysis dependent rate after ARF is 5 and renal recovery rate is 286 Therefore the issue concerned is to increase the survival rate and renal recovery rate after acute renal failure
Perioperative ischemic reperfusion injury may result in acute renal failure ARF from which patients can invariably recover However there remains a large number of patients whose kidneys fail to recover from ARF and therefore long-term dialysis is required The dys-regulation of the inflammatory response in critically ill patients has been implicated as an important mechanism underlying the development of multiple organ system dysfunction septic shock and death Furthermore an increase in oxidative stress is considered an important pathogenic mechanism in the development of ischemic and toxic renal tubular injury We hypothesize that extensive immune dys-regulation and increased oxidative stress might be an important factor leading to ARF andor associated with their all-cause mortality in critically ill patients
In this study we will find out 1 first year the relationship between cytokine storm and free radical storm with urine output during post-surgical ARF and the effect of renal replacement therapy on serum cytokines and free radical level 2 2nd year the difference outcome between low low-efficient daily dialysis SLEDD and low low-efficient daily dialysis-hemofiltration SLEDD-f the pharmacokinetics of the SLEDD 3 the 3rd year we sill established the disease severity score of post-operative ARF patients NSARF score and focus on long-term outcomes for survivors of postoperative ARF From diagnosis to prognosis we will incorporate important markers of disease diagnosis treatment and long term outcome Finally we hope to improve the mortality and the life quality of postoperative ARF
Perioperative ischemic reperfusion injury may result in acute renal failure ARF from which patients can invariably recover However there remains a large number of patients whose kidneys fail to recover from ARF and therefore long-term dialysis is required The dys-regulation of the inflammatory response in critically ill patients has been implicated as an important mechanism underlying the development of multiple organ system dysfunction septic shock and death Furthermore an increase in oxidative stress is considered an important pathogenic mechanism in the development of ischemic and toxic renal tubular injury We hypothesize that extensive immune dys-regulation and increased oxidative stress might be an important factor leading to ARF andor associated with their all-cause mortality in critically ill patients
In this study we will find out 1 first year the relationship between cytokine storm and free radical storm with urine output during post-surgical ARF and the effect of renal replacement therapy on serum cytokines and free radical level 2 2nd year the difference outcome between low low-efficient daily dialysis SLEDD and low low-efficient daily dialysis-hemofiltration SLEDD-f the pharmacokinetics of the SLEDD 3 the 3rd year we sill established the disease severity score of post-operative ARF patients NSARF score and focus on long-term outcomes for survivors of postoperative ARF From diagnosis to prognosis we will incorporate important markers of disease diagnosis treatment and long term outcome Finally we hope to improve the mortality and the life quality of postoperative ARF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 31MD03 | None | None | None |