Ignite Creation Date:
2024-05-05 @ 5:25 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00454623
Status:
UNKNOWN
Last Update Posted:
2007-04-02
First Post:
2007-03-29
Brief Title:
Normal Serum Adiponectin Levels in Females
Sponsor:
The Cooper Health System
Organization:
The Cooper Health System
Study Overview
Official Title:
Normal Serum Adiponectin Levels in Females During the Childbearing Ages and Normal Serum Adiponectin Levels in Pregnancy
Status:
UNKNOWN
Status Verified Date:
2007-03
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to establish the normal levels of the hormone adiponectin in women Adiponectin is a newly discovered hormone which is said to be associated with many changes in the human body and metabolism The researchers aim is to establish the normal levels of this hormone Hence the researchers can identify people with abnormal levels who may be at risk of diseases and can do more studies to help them
Detailed Description:
The prevalence of obesity has increased dramatically in recent years It is commonly associated with type 2 diabetes coronary artery disease and hypertension and the coexistence of these diseases has been termed the metabolic syndrome White Adipose Tissue WAT has been increasingly recognized as an important endocrine organ that secretes a number of biologically active adipokines Of these adipokines adiponectin has recently attracted much attention because of its antidiabetic and antiatherogenic effects and is expected to be a novel therapeutic tool for diabetes and the metabolic syndrome Adiponectin directly regulates glucose metabolism and insulin sensitivity by activation of AMPK
Adiponectin expression is reduced in obese insulin-resistant rodent models Plasma adiponectin levels are also decreased in an obese rhesus monkey model that frequently develops type 2 diabetes Levels have also been reported to be reduced in obese humans particularly those with visceral obesity and to correlate inversely with insulin resistance Prospective and longitudinal studies have shown that lower adiponectin levels are associated with a higher incidence of diabetes
Hypoadiponectinemia has been demonstrated to be independently associated with the metabolic syndrome Reduced plasma adiponectin levels are also commonly observed in a variety of states frequently associated with insulin resistance such as cardiovascular disease ischemic heart disease and hypertension In women lower adiponectin levels were associated with breast cancer endometrial cancer and polycystic ovarian syndrome
By establishing normal serum levels of Adiponectin researchers will be able to demonstrate deviations from the norm associated with investigated diseases and variables When applied to pregnancy it will help identify obstetrical complications associated with abnormal levels
Adiponectin expression is reduced in obese insulin-resistant rodent models Plasma adiponectin levels are also decreased in an obese rhesus monkey model that frequently develops type 2 diabetes Levels have also been reported to be reduced in obese humans particularly those with visceral obesity and to correlate inversely with insulin resistance Prospective and longitudinal studies have shown that lower adiponectin levels are associated with a higher incidence of diabetes
Hypoadiponectinemia has been demonstrated to be independently associated with the metabolic syndrome Reduced plasma adiponectin levels are also commonly observed in a variety of states frequently associated with insulin resistance such as cardiovascular disease ischemic heart disease and hypertension In women lower adiponectin levels were associated with breast cancer endometrial cancer and polycystic ovarian syndrome
By establishing normal serum levels of Adiponectin researchers will be able to demonstrate deviations from the norm associated with investigated diseases and variables When applied to pregnancy it will help identify obstetrical complications associated with abnormal levels
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None