Ignite Creation Date:
2024-05-06 @ 4:22 PM
Last Modification Date:
2024-10-26 @ 2:08 PM
Study NCT ID:
NCT04960774
Status:
UNKNOWN
Last Update Posted:
2021-07-14
First Post:
2021-06-16
Brief Title:
Risk Factors for Severe Periodontitis in 30 to 40 Year Olds a Retrospective Study
Sponsor:
Second Affiliated Hospital School of Medicine Zhejiang University
Organization:
Second Affiliated Hospital School of Medicine Zhejiang University
Study Overview
Official Title:
Human Subject Research Ethics Committee 2nd Affiliated Hospital School of Medicine Zhejiang University China
Status:
UNKNOWN
Status Verified Date:
2021-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Periodontitis is one of the most common oral diseases which is characterized by alveolar bone resorption and destruction In China as a major country in the incidence of periodontitis there is a huge population of patients with severe periodontitis and the incidence rate is as high as 121-161 Previous studies have suggested that the prevalence and severity of periodontal disease increase with age However recent articles on meta analysis and related epidemiological investigations suggest that the prevalence of severe periodontitis does not increase with age and the prevalence of SP remains at about 10 even in the elderly In order to comprehensively analyze the risk factors of this population it is inseparable from the analysis of gene polymorphism At present it is considered that the main genes that may be related to the severity of periodontitis are IL-1 α-889 rhIL-talk 1 β 3953 6-174 10-597 CD14-260 CD14-159 MMP1-1607 and so on which may be related to the severity of periodontitis
Detailed Description:
Periodontitis is one of the most common oral diseases which is characterized by alveolar bone resorption and destruction In 2010 severe periodontitis severe periodontitisSP had become the sixth largest epidemic disease in the world affecting 108 of the global population or 743 million people In China as a major country in the incidence of periodontitis there is a huge population of patients with severe periodontitis and the incidence rate is as high as 121-161 The fourth National Oral Health Epidemiological Survey also found that the oral health of residents aged 35-44 is generally poor which has become a major obstacle to the implementation of the Healthy China 2030 strategy Previous studies have suggested that the prevalence and severity of periodontal disease increase with age The possible reasons for this phenomenon are as followsFirst the cumulative effect of attachment level and bone loss with ageSecond changes related to the aging process such as drug intake decreased immune function and changes in nutritional status interact with risk factors can increase the susceptibility to periodontitis However recent articles on meta analysis and related epidemiological investigations suggest that the prevalence of severe periodontitis does not increase with age and the prevalence of SP remains at about 10 even in the elderly In addition the global meta analysis with large sample size showed that the prevalence of SP increased sharply between 30 and 40 years old peaked at about 38 years old This trend of severe periodontitis with age is not consistent with our traditional cognition and there is no related research to explain this trend However it is found that 30-40 years old patients with severe periodontitis account for a large proportion so it is of great significance to analyze the risk factors of this group and carry out targeted prevention and control In order to comprehensively analyze the risk factors of this population it is inseparable from the analysis of gene polymorphism Studies related to severe periodontitis gene polymorphism are mainly focused on Toll-like receptor Toll-likereceptors interleukin interleukinIL immunoglobulin receptor Immunoglobulinreceptors formyl peptide receptor Formylpeptide receptor vitamin D receptor VitaminDreceptor VDR and matrix metalloproteinases matrixmetalloproteinaseMMP At present it is considered that the main genes that may be related to the severity of periodontitis are IL-1 α-889 rhIL-talk 1 β 3953 6-174 10-597 CD14-260 CD14-159 MMP1-1607 and so on which may be related to the severity of periodontitis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None