Ignite Creation Date:
2024-05-05 @ 5:25 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00455793
Status:
COMPLETED
Last Update Posted:
2013-12-02
First Post:
2007-04-02
Brief Title:
Subclinical Atherosclerosis in HIV-infected Patients
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Subclinical Atherosclerosis in HIV-infected Patients
Status:
COMPLETED
Status Verified Date:
2013-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We will obtain data using multi-slice CT technology to detect subclinical coronary disease in the HIV population Determination of subclinical cardiovascular disease using noninvasive technology and elucidation of the associated risk factors will help to guide targeted therapy to prevent cardiovascular events in this patient population
We will investigate the prevalence of coronary plaque lesions and coronary artery calcifications in men and women with HIV disease as determined by 64-row multidetector computed tomography MDCT and MDCT coronary angiography in comparison to age-matched control subjects without HIV infection We hypothesize that evidence of coronary artery calcification and coronary plaque lesions as seen by MDCT will be present in individuals with HIV more than non-HIV control subjects of the same age We also hypothesize the degree of atherosclerosis will be increased in HIV patients compared to control subjects
We will evaluate the metabolic and inflammatory factors associated with coronary artery disease in HIV-infected individuals We hypothesize that traditional cardiac risk factors as well as metabolic and inflammatory changes associated with HIV and its treatment such as dyslipidemia increased secretion of inflammatory markers decreased adiponectin increased insulin resistance and increased visceral fat may be associated with coronary artery disease in HIV-infected individuals
We will investigate the prevalence of coronary plaque lesions and coronary artery calcifications in men and women with HIV disease as determined by 64-row multidetector computed tomography MDCT and MDCT coronary angiography in comparison to age-matched control subjects without HIV infection We hypothesize that evidence of coronary artery calcification and coronary plaque lesions as seen by MDCT will be present in individuals with HIV more than non-HIV control subjects of the same age We also hypothesize the degree of atherosclerosis will be increased in HIV patients compared to control subjects
We will evaluate the metabolic and inflammatory factors associated with coronary artery disease in HIV-infected individuals We hypothesize that traditional cardiac risk factors as well as metabolic and inflammatory changes associated with HIV and its treatment such as dyslipidemia increased secretion of inflammatory markers decreased adiponectin increased insulin resistance and increased visceral fat may be associated with coronary artery disease in HIV-infected individuals
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None