Ignite Creation Date:
2024-05-06 @ 4:18 PM
Last Modification Date:
2024-10-26 @ 2:08 PM
Study NCT ID:
NCT04945681
Status:
UNKNOWN
Last Update Posted:
2021-06-30
First Post:
2021-06-14
Brief Title:
Evaluating the Effectiveness of a Pneumococcal Immunisation Campaign in a Camp for Internally Displaced People
Sponsor:
London School of Hygiene and Tropical Medicine
Organization:
London School of Hygiene and Tropical Medicine
Study Overview
Official Title:
Evaluating the Effectiveness of a Pneumococcal Immunisation Campaign in a Camp for Internally Displaced People A Non-randomised Quasi-experimental Phase IV Intervention Study
Status:
UNKNOWN
Status Verified Date:
2021-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EEPICC
Brief Summary:
Pneumococcal conjugate vaccine PCV is used routinely worldwide as part of infant immunisations to prevent acquisition of Streptococcus pneumoniae the aetiologic agent responsible for a large proportion of early childhood pneumonia and invasive disease However PCV has seen minimal uptake in populations affected by forced displacement and humanitarian crises where the burden of pneumococcal disease is plausibly elevated
This study seeks to generate evidence on appropriate vaccination strategies for crisis-affected populations The investigators plan to exhaustively vaccinate children up to 15 years in a camp for displaced persons outside Hargeisa the capital of Somaliland The study will deliver PCV in a campaign modality so as to achieve both short- and long-term herd immunity effects that the investigators hypothesise will reduce population-wide nasopharyngeal S pneumoniae transmission and thereby protect young children from pneumococcal disease
The study will adopt a quasi-experimental design with baseline and post-intervention surveys to evaluate changes in pneumococcal carriage complemented by safety assessment in children aged over 2 years for whom PCV safety data are scarce and longitudinal data collection on incidence of pneumonia and antibiotic prescriptions in the camp
This study seeks to generate evidence on appropriate vaccination strategies for crisis-affected populations The investigators plan to exhaustively vaccinate children up to 15 years in a camp for displaced persons outside Hargeisa the capital of Somaliland The study will deliver PCV in a campaign modality so as to achieve both short- and long-term herd immunity effects that the investigators hypothesise will reduce population-wide nasopharyngeal S pneumoniae transmission and thereby protect young children from pneumococcal disease
The study will adopt a quasi-experimental design with baseline and post-intervention surveys to evaluate changes in pneumococcal carriage complemented by safety assessment in children aged over 2 years for whom PCV safety data are scarce and longitudinal data collection on incidence of pneumonia and antibiotic prescriptions in the camp
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None