Ignite Creation Date:
2024-05-06 @ 4:15 PM
Last Modification Date:
2024-10-26 @ 2:06 PM
Study NCT ID:
NCT04921774
Status:
UNKNOWN
Last Update Posted:
2022-08-09
First Post:
2021-06-01
Brief Title:
Research on Patients With Heart Transplantation
Sponsor:
Guangdong Provincial Peoples Hospital
Organization:
Guangdong Provincial Peoples Hospital
Study Overview
Official Title:
Research on the Pathogenesis and Early Diagnosis of Acute Rejection in Patients With Heart Transplantation by Using Multimodality MR Imaging Combined With Circulating Exosomal miRNA Expression
Status:
UNKNOWN
Status Verified Date:
2022-08
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This trial was a single-center prospective cohort studyThe purpose of this clinical research is to evaluate the accuracy of combining multimodality MR Imaging with circulating exosomal miRNA expression to diagnose acute rejection in patients with heart transplantationthus it may be helpful for timely intervention to improve the patients prognosis
Detailed Description:
Acute rejection AR after heart transplantation remains the major factor limiting long-term survival and an independent risk factor for chronic allograft vasculopathy Currently there remains no reliable non-invasive method to detect AR Multimodality magnetic resonance MR imaging shows accurate detection of myocardial damage such as interstitial cell infiltrates edema hemorrhage myocyte damagenecrosis and capillary stenosis or fragmentation It turned out that the indicators in both MR imaging and circulating exosomal miRNA showed difference between patients with and without AR in our initial research work Therefore we hypothesize that circulating exosomal miRNA may play an important role in the activation of signaling pathway in AR after heart transplantation which can be detected by multimodality MR imaging All transplant recipients receiving transplantation follow-up care in our center were approached In the present research we aim to combine multimodality MR imaging with circulating exosomal miRNA to explore a new evaluation methodology and platform for early and noninvasive detection of AR after heart transplantation We attempt to confirm contribution of circulating exosomal miRNA to myocardial damage of AR through biopsy-proven allograft rejection and animal heterotopic heart transplantation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None