Ignite Creation Date:
2024-05-06 @ 4:15 PM
Last Modification Date:
2024-10-26 @ 2:06 PM
Study NCT ID:
NCT04920539
Status:
RECRUITING
Last Update Posted:
2023-12-05
First Post:
2021-05-17
Brief Title:
In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans
Sponsor:
Yale University
Organization:
Yale University
Study Overview
Official Title:
In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes
Detailed Description:
In this study the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes To test these hypotheses the investigators propose defining the epigenomic and transcriptomic alterations at single cell resolution in peripheral blood mononuclear cells by administering THC to humans with and without HIV infection The THC-associated epigenomictranscriptomic alterations will be linked to genomic variants to understand the causal effects of THC response in immune cells
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DA052846 | NIH | None | httpsreporternihgovquickSearchR01DA052846 |