Ignite Creation Date:
2024-05-05 @ 5:24 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00447512
Status:
COMPLETED
Last Update Posted:
2007-10-31
First Post:
2007-03-13
Brief Title:
Effects of Ghrelin on the Sleep-EEG and Nocturnal Secretion of Hormones
Sponsor:
Max-Planck-Institute of Psychiatry
Organization:
Max-Planck-Institute of Psychiatry
Study Overview
Official Title:
Effects of Ghrelin on the Sleep-EEG and Nocturnal Secretion of Hormones
Status:
COMPLETED
Status Verified Date:
2007-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Ghrelin an acylated peptide consisting of 28 amino acids is the endogenous ligand of the growth hormone secretagogue receptor GHS-R It is synthesized predominantly in the stomach but has been also identified in a variety of other organs Alike a wide range of central and peripheral endocrine and non-endocrine actions has been described e g being a releasing factor of growth hormone prolactin and ACTH a modulator of cell proliferation and apoptosis a regulator of sleep-wake regulation and a orexigenic hormone Aims of this study are
A To determine the effect of exogenous ghrelin on sleep-EEG variables and hormones of the hypothalamic-pituitary-adrenocortical HPA axis the gonadotropic axis and the hypothalamic-pituitary-gonadal axis in healthy subjects of both genders age groups 20-30 35-45 60-70 years
B To determine the effect of exogenous ghrelin on sleep-EEG variables and hormones of the HPA axis the gonadotropic axis and the hypothalamic-pituitary-gonadal axis in patients with major depression age range 20-65 years
A To determine the effect of exogenous ghrelin on sleep-EEG variables and hormones of the hypothalamic-pituitary-adrenocortical HPA axis the gonadotropic axis and the hypothalamic-pituitary-gonadal axis in healthy subjects of both genders age groups 20-30 35-45 60-70 years
B To determine the effect of exogenous ghrelin on sleep-EEG variables and hormones of the HPA axis the gonadotropic axis and the hypothalamic-pituitary-gonadal axis in patients with major depression age range 20-65 years
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None