Ignite Creation Date:
2024-05-06 @ 4:15 PM
Last Modification Date:
2024-10-26 @ 2:06 PM
Study NCT ID:
NCT04924426
Status:
UNKNOWN
Last Update Posted:
2021-06-14
First Post:
2021-06-10
Brief Title:
Interest of TTC for the Early Diagnosis of Acute Myocardial Infarction at Autopsy
Sponsor:
University Hospital Montpellier
Organization:
University Hospital Montpellier
Study Overview
Official Title:
Interest of Triphenyl Tetrazolium Chloride TTC for the Early Diagnosis of Acute Myocardial Infarction at Autopsy
Status:
UNKNOWN
Status Verified Date:
2021-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
INFARCTOPSY
Brief Summary:
Ischemic heart disease is the leading cause of death worldwide and the leading cause of sudden cardiac death However its post-mortem diagnosis is particularly difficult because the gross examination of the heart is usually normal at the autopsy The diagnosis is therefore often based on a set of indirect arguments such as the patients medical and clinical history and the degree of occlusion of the coronary arteries The formal diagnosis of acute myocardial infarction AMI currently relies on standard histological examination However histological findings often require a prolonged survival time of several hours to be highlighted Triphenyltetrazolium chloride TTC is a salt that reacts with lactate dehydrogenases contained in still viable myocardial cells forming a red pigment visible to the naked eye 135 triphenylformazan Ischemia-induced cell death which occurs within minutes of the causative event is responsible for the leakage of lactate deshydrogenase into the extracellular medium and thus results in the absence of formazan formation in the infarcted area which displays an easily identifiable pale unstained color It has been suggested that the use of TTC would allow the identification of MI as early as one hour of survival in animal models before the usual macroscopic and microscopic signs are visible It could therefore represent an attractive forensic tool for the early diagnosis of AMI at the autopsy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None