Ignite Creation Date:
2024-05-05 @ 1:18 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001714
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Magnetization Transfer Quantitation and Characterization for Clinical Scanners
Sponsor:
National Institutes of Health Clinical Center CC
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Magnetization Transfer Quantitation and Characterization for Clinical Scanners
Status:
COMPLETED
Status Verified Date:
2001-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project will measure magnetization transfer MT parameters on normal subjects using two novel approaches The first is the investigation of asymmetric MT effects with respect to the zero or on-resonance reference point The technique measures the difference in MT effect between two symmetrically positioned off-resonance MT pulses in the positive and negative frequency ranges Prior research with this technique in the kidney show a difference in the macromolecular lineshape that correlates to a specific metabolite The second approach utilizing a subset of the acquisitions from the first approach will test newly developed formulation to calculate the macromolecular fraction or fraction of proton density that accounts for MT We foresee these measurements may significantly develop our understanding of MT and introduce diagnostic and quantitative tools to study human tissues
Detailed Description:
This project will measure magnetization transfer MT parameters on normal subjects using two novel approaches The first is the investigation of asymmetric MT effects with respect to the zero or on-resonance reference point The technique measures the difference in MT effect between two symmetrically positioned off-resonance MT pulses in the positive and negative frequency ranges Prior research with this technique in the kidney show a difference in the macromolecular lineshape that correlates to a specific metabolite The second approach utilizing a subset of the acquisitions from the first approach will test newly developed formulation to calculate the macromolecular fraction or fraction of proton density that accounts for MT We foresee these measurements may significantly develop our understanding of MT and introduce diagnostic and quantitative tools to study human tissue
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-CC-0084 | None | None | None |