Ignite Creation Date:
2024-05-06 @ 4:12 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04900701
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-05-22
First Post:
2021-05-20
Brief Title:
The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults
Sponsor:
University of Exeter
Organization:
University of Exeter
Study Overview
Official Title:
The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PIE
Brief Summary:
In healthy middle-aged men and women what is the effect of dietary energy restriction and energy surplus on daily muscle protein synthesis rates and muscle morphology compared to energy balance during free-living and immobilisation
Detailed Description:
Background Age related muscle tissue loss which is associated with a number of negative health outcomes is partially caused by blunted muscle protein synthesis rates MPS in response to food ingestion which is exacerbated by muscle disuse Concomitantly consuming an energy balanced diet appears to become more challenging with advancing age due to a reduction in appetite Of concern is that the impact of energy intake on muscle protein metabolism during ageing is poorly characterised
Objective To determine daily MPS and muscle morphology in response to differing energy intakes in free-living conditions and during immobilisation
Methods Healthy middle-aged volunteers will consume a hypocaloric energy-balanced or hypercaloric diet providing 14 gkgday protein over a three-day free-living period and a three day period of single leg immobilisation Deuterium oxide and MRI scans will be used to measure daily MPS and muscle size respectively
Value The study will determine the effect of energy intake per se on daily muscle protein synthesis rates and muscle size in free-living and immobilised conditions This will inform how energy provision modulates tissue loss with ageing and how this interacts with the catabolic stress of muscle disuse
Objective To determine daily MPS and muscle morphology in response to differing energy intakes in free-living conditions and during immobilisation
Methods Healthy middle-aged volunteers will consume a hypocaloric energy-balanced or hypercaloric diet providing 14 gkgday protein over a three-day free-living period and a three day period of single leg immobilisation Deuterium oxide and MRI scans will be used to measure daily MPS and muscle size respectively
Value The study will determine the effect of energy intake per se on daily muscle protein synthesis rates and muscle size in free-living and immobilised conditions This will inform how energy provision modulates tissue loss with ageing and how this interacts with the catabolic stress of muscle disuse
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None