Ignite Creation Date:
2024-05-06 @ 4:12 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04901208
Status:
COMPLETED
Last Update Posted:
2024-03-22
First Post:
2021-04-30
Brief Title:
Acute Effects of Vaping Nicotine on Cognition in Young Adults
Sponsor:
Yale University
Organization:
Yale University
Study Overview
Official Title:
Acute Effects of Vaping Nicotine on Reward Processing and Inhibitory Control in Young Adults
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine reward processing and cognitive control both with and without the influence of vaporized nicotine in young adults with no history of cigarette use using EEG and fMRI The goal is to determine whether acute nicotine administration using a Juul device would impact functional correlates of reward and inhibitory control in people who commonly use juul devices
Detailed Description:
Aim 1 To examine reward processing both with and without the influence of vaporized nicotine in young adults with no history of cigarette use using EEG and fMRI The goal is to determine whether acute nicotine administration using a Juul device would impact functional correlates of distinguishable reward processes anticipatory and consummatory reward in young adults who commonly use juul devices Predictions are that juul use will have an impact on activity in the striatum resulting in reduced activation in fMRI and smaller amplitudes in event-related potentials ERP in response to reward cues and reward feedback
Aim 2 To examine cognitive control both with and without the influence of vaporized nicotine in young adults with no history of cigarette use using EEG and fMRI The goal is to determine whether acute nicotine administration using a Juul device would impact functional correlates of behavioral inhibition in young adults who commonly use juul devices Predictions are that juul use will affect the inhibitory circuit including the anterior cingulate and the dorso-lateral prefrontal cortex resulting in decreased activation in these regions during fMRI and reductions in the FRN and P300 ERP responses in response to inhibitions and to commission errors Predictions also include that inhibitory control behavior will be impaired after juul use
Aim 3 To establish feasibility of naturalistic use of vaping devices for nicotine administration and observing the effects in the laboratory
Aim 2 To examine cognitive control both with and without the influence of vaporized nicotine in young adults with no history of cigarette use using EEG and fMRI The goal is to determine whether acute nicotine administration using a Juul device would impact functional correlates of behavioral inhibition in young adults who commonly use juul devices Predictions are that juul use will affect the inhibitory circuit including the anterior cingulate and the dorso-lateral prefrontal cortex resulting in decreased activation in these regions during fMRI and reductions in the FRN and P300 ERP responses in response to inhibitions and to commission errors Predictions also include that inhibitory control behavior will be impaired after juul use
Aim 3 To establish feasibility of naturalistic use of vaping devices for nicotine administration and observing the effects in the laboratory
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2UL1TR001863-06 | NIH | None | None |
| 1K01DA042937-01A1 | NIH | None | httpsreporternihgovquickSearch1K01DA042937-01A1 |