Ignite Creation Date:
2024-05-06 @ 4:12 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04901156
Status:
COMPLETED
Last Update Posted:
2023-09-13
First Post:
2021-05-20
Brief Title:
rTMS and Multi-Modality Aphasia Therapy for Post-Stroke Aphasia
Sponsor:
University of Calgary
Organization:
University of Calgary
Study Overview
Official Title:
A Randomized Pilot Trial of Repetitive Transcranial Magnetic Stimulation rTMS and Multi-Modality Aphasia Treatment M-MAT for Post-Stroke Non-Fluent Aphasia
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TMAT
Brief Summary:
Many stroke survivors experience aphasia a loss or impairment of language affecting the production or understanding of speech One common type of aphasia is known as non-fluent aphasia Patients with non-fluent aphasia have difficulty formulating grammatical sentences often producing short word fragments despite having a good understanding of what others are trying to communicate to them Speech language pathologists SLPs play a central role rehabilitating persons with aphasia and administer therapy in an attempt to improve communication skills Despite standard therapy approximately 50 of individuals who experience aphasia acutely continue to have language deficits more than 6 months post-stroke
In most people Brocas area is dominant in the left side of the brain Following a left-sided stroke the right-sided homologue of Brocas area the pars triangularis may adopt language function Unfortunately reorganizing language to the right side of the brain seems to be less effective than restoring function to the left hemisphere Repetitive transcranial magnetic stimulation rTMS a form of non-invasive brain stimulation can be used to suppress activity of specific regions in the right side of the brain to promote recovery of function in the perilesional area Despite preliminary success in existing studies using rTMS in post-stroke aphasia there is much work to be done to better understand the mechanisms underlying recovery Responses to rTMS have been positive yet heterogenous which may be related to timing of treatments following stroke
In most people Brocas area is dominant in the left side of the brain Following a left-sided stroke the right-sided homologue of Brocas area the pars triangularis may adopt language function Unfortunately reorganizing language to the right side of the brain seems to be less effective than restoring function to the left hemisphere Repetitive transcranial magnetic stimulation rTMS a form of non-invasive brain stimulation can be used to suppress activity of specific regions in the right side of the brain to promote recovery of function in the perilesional area Despite preliminary success in existing studies using rTMS in post-stroke aphasia there is much work to be done to better understand the mechanisms underlying recovery Responses to rTMS have been positive yet heterogenous which may be related to timing of treatments following stroke
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None