Ignite Creation Date:
2024-05-06 @ 4:11 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04900545
Status:
COMPLETED
Last Update Posted:
2022-12-01
First Post:
2021-05-20
Brief Title:
Effect of Genetic Polymorphisms on Response to Beta Blocker Therapy in Egyptian Patients
Sponsor:
Mohamed Saleh Fayed
Organization:
Ain Shams University
Study Overview
Official Title:
Effect of Genetic Polymorphisms on Response to Beta Blocker Therapy in Egyptian Patients
Status:
COMPLETED
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Beta-blockers represent a cornerstone for the treatment of coronary artery disease CAD Their protective effect is based on the negative inotropic and chronotropic features which have been tested in a large number of randomized controlled trials both in patients with myocardial infarction MI and in those with stable angina demonstrating a reduction of adverse cardiovascular events a relief of symptoms and a reduction of myocardial ischemia
However considerable interpatient variability in response to β-blockers has been reported which indicates that a considerable proportion of β-blocker-treated patients do not achieve the warranted cardio protection with β- blockers This highlights the importance of identifying biomarkers associated with variability in response to β-blockers to improve the current approach for β- blocker selection which seems to be suboptimal
This study aims to study the effect of polymorphism in adrenergic beta receptors on beta-blocker response in Egyptian patients
However considerable interpatient variability in response to β-blockers has been reported which indicates that a considerable proportion of β-blocker-treated patients do not achieve the warranted cardio protection with β- blockers This highlights the importance of identifying biomarkers associated with variability in response to β-blockers to improve the current approach for β- blocker selection which seems to be suboptimal
This study aims to study the effect of polymorphism in adrenergic beta receptors on beta-blocker response in Egyptian patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None