Ignite Creation Date:
2024-05-06 @ 4:11 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04904432
Status:
UNKNOWN
Last Update Posted:
2022-10-27
First Post:
2021-04-15
Brief Title:
PLIN1 Variants in Precocious ACS SCAPLIN
Sponsor:
Assistance Publique Hopitaux De Marseille
Organization:
Assistance Publique Hopitaux De Marseille
Study Overview
Official Title:
Involvement of Perilipin-1 Variants in Precocious Acute Coronary Syndrome
Status:
UNKNOWN
Status Verified Date:
2022-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to identify a genetic predisposition factor of precocious acute coronary syndrome occurrence ACS ACS is a major public health problem and the first cause of mortality in the world It can be due to several risk factor such as heredity the investigators make the hypothesis that occurrence of early ACS defined as 50yo for men and 55yo for women could be the initiatory event of a mild form of genetic lipodystrophy Our previous study shown an occurrence risk of ACS about 83 in patients carrying a mutation in the PLIN1 gene versus patients without a mutation The PLIN1 gene encode for perilipin 1 protein localized on the lipid droplet surface This protein phosphorylation activates the triglycerides lipolysis Our goals in this study are multiple to validate the high frequency of mutations in this gene in patients with early ACS to determine differences in triglycerides metabolism and also relapse rate between carrier and non-carrier patients of mutation in PLIN1 Our first aim will be to carry out the inclusion of 200 patients with precocious ACS This will allow us to obtain around 15 patients carrying a mutation in the PLIN1 gene based on our previous study the investigators will reprogramme patients cells carrying or not a PLIN1 mutation in human Induce Pluripotent Stem cells hIPSc These hIPSc will be differentiated in cell types of interest as adipocytes or macrophages the investigators will then study triglycerides metabolism lipid droplet formation localization and phosphorylation of perlipin 1 in these cells and atheroma plaque formation Finally the investigators will study clinical data such as relapse rate and searching for correlation with PLIN1 mutation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None