Ignite Creation Date:
2024-05-06 @ 4:11 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04900779
Status:
UNKNOWN
Last Update Posted:
2021-05-25
First Post:
2021-05-20
Brief Title:
Evaluation of Glycocalyx in Major Abdominal and Thoracic Surgery
Sponsor:
Hospital Universitari Vall dHebron Research Institute
Organization:
Hospital Universitari Vall dHebron Research Institute
Study Overview
Official Title:
Prospective Observational Study to Evaluate Glycocalyx Alteration in Major Abdominal and Thoracic Surgery
Status:
UNKNOWN
Status Verified Date:
2021-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
The glycocalyx is a fundamental component of the endothelial barrier and alterations at this level have been shown to exacerbate the inflammatory response in the microcirculation Its degradation in the surgical patient has been tested in interventions that involve regional or general ischemia for example in cardiac surgery major vascular surgery or transplantation On interventions that do not involve ischemic events the literature is limited such is the case of those patients undergoing major abdominal and thoracic surgery
Objective
Assess whether there is a glycocalyx degradation in major elective abdominal and thoracic surgery measured as an increase in plasma syndecane-1 levels during the first 24 hours of postoperative care
Methodology
Prospective observational study in patients undergoing major elective thoracic and abdominal surgery at the University Hospital Vall dHebrón Measurement of the syndecane-1 plasma levels are going to be done during the first 24 hours after the intervention It is intended to evaluate whether its elevation is related to anesthetic perioperative factors and if it has an impact con morbildity and mortality in the following 6 months after the procedure
The glycocalyx is a fundamental component of the endothelial barrier and alterations at this level have been shown to exacerbate the inflammatory response in the microcirculation Its degradation in the surgical patient has been tested in interventions that involve regional or general ischemia for example in cardiac surgery major vascular surgery or transplantation On interventions that do not involve ischemic events the literature is limited such is the case of those patients undergoing major abdominal and thoracic surgery
Objective
Assess whether there is a glycocalyx degradation in major elective abdominal and thoracic surgery measured as an increase in plasma syndecane-1 levels during the first 24 hours of postoperative care
Methodology
Prospective observational study in patients undergoing major elective thoracic and abdominal surgery at the University Hospital Vall dHebrón Measurement of the syndecane-1 plasma levels are going to be done during the first 24 hours after the intervention It is intended to evaluate whether its elevation is related to anesthetic perioperative factors and if it has an impact con morbildity and mortality in the following 6 months after the procedure
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None