Ignite Creation Date:
2024-05-06 @ 4:10 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04897984
Status:
COMPLETED
Last Update Posted:
2021-09-28
First Post:
2021-05-18
Brief Title:
LEAP2 Kinetics in Healthy Individuals
Sponsor:
University Hospital Gentofte Copenhagen
Organization:
University Hospital Gentofte Copenhagen
Study Overview
Official Title:
The Kinetics of LEAP2 in Man
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to investigate the kinetics of the naturally occurring peptide liver-enriched antimicrobial peptide 2 LEAP-2 in healthy volunteers The overall objective is to investigate the physiological importance of LEAP-2 in healthy subjects
Detailed Description:
In a recent study the molecular phenotype of enteroendocrine cells in the small intestine before and after Roux-en-Y Gastric Bypass RYGB surgery in obese individuals was examined Enteroendocrine cells were identified and isolated from intestinal biopsies and analysed for differentially expressed genes by Illumina High Throughput RNA-sequencing It was discovered that the gene encoding liver-enriched antimicrobial peptide 2 LEAP2 a naturally occurring peptide in humans was significantly upregulated compared to baseline expression Interestingly LEAP2 was recently shown to antagonize ghrelin function in response to feeding in mice Moreover the mature murine LEAP2 peptide is identical in mice and humans Thus LEAP2 has been identified as an endogenous peptide that may be able to alter feeding behaviour and maintenance of glucose levels during calorie restriction
This study aims to investigate the kinetics of exogenous LEAP2 in healthy subjects
This study aims to investigate the kinetics of exogenous LEAP2 in healthy subjects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None