Ignite Creation Date:
2024-05-05 @ 5:23 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00449735
Status:
COMPLETED
Last Update Posted:
2018-06-12
First Post:
2007-03-19
Brief Title:
Quinolone Resistance in Bloodstream Isolates of Escherichia Coli
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Quinolone Resistance in Bloodstream Isolates of Escherichia Coli
Status:
COMPLETED
Status Verified Date:
2018-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of E coli Additionally the adequacy of empiric antibiotic therapy for E coli bloodstream infections will be assessed Finally outcome will be recorded - this is all-cause mortality at 28 days from the time of the first positive blood culture Hypothesis Ciprofloxacin resistant strains are associated with admission from nursing home and with prior quinolone use
Detailed Description:
The following information will be collected age sex occupation hospital location at the time of positive culture ER medical ward ICU etc date of positive culture prior hospitalization receipt of outpatient dialysis home care or other regular medical care eg outpatient chemotherapy presence of invasive devices receipt of antibiotics including their type and whether they were adequate for the resistance profile of the organism prior positive microbiologic cultures time and location of positive cultures underlying diseases and severity of illness presence of urinary or intravascular devices recent immunomodulative therapies or radiation therapy physical exam findings laboratory and radiographical data antimicrobial usage within 30 days of onset of the infection microbiological data and resistance patterns choice of antibiotics once organism identified bacteriological outcomes laboratory results demographic information medications clinical outcomegender height weight ethnicity and past medical history We will collect information retrospectively
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None