Ignite Creation Date:
2024-05-06 @ 4:10 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04898621
Status:
COMPLETED
Last Update Posted:
2023-06-07
First Post:
2021-05-14
Brief Title:
Dietary Fructose on Microbiota and Hepatosteatosis
Sponsor:
Shanghai Zhongshan Hospital
Organization:
Shanghai Zhongshan Hospital
Study Overview
Official Title:
The Effect of Dietary Fructose on Gut Microbiota and Hepatosteatosis in Healthy Men
Status:
COMPLETED
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The consumption of sugar-sweetened beverages SSB has increased steadily over the past decades resulting in the dramatic increase of fructose intake as it is one of the main ingredients of artificial sweeteners Recently large epidemiological studies have documented the association between a high-fructose-diet and hepatic steatosis and other metabolic disorders So it is interesting for scientists to explore the underlying mechanism This study aims to investigate the effect of dietary fructose and gut microbiota and the hepatosteatosis in healthy men Serum and fecal metabolomics will be investigated
Detailed Description:
This is a single center randomized controlled study 60 healthy men will be recruited according to the inclusion criteria All subjects are randomly allocated to Group A and Group B who orally takes 75g and 150g fructose daily respectively Subjects in Group A will be instructed to drink fructose solution containing 75g fructose per day and those in Group B will be instructed to drink fructose solution containing 150g fructose per day The intervention will last four weeks The anthropomentric data will be collect with questionnaire and serum and fecal samples collected at baseline and the end of the intervention The effect and mutual interaction of dietary fructose and microbiota will be explored The effect of dietary fructose on hepatosteatosis will be investigated as well
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None