Ignite Creation Date:
2024-05-06 @ 4:10 PM
Last Modification Date:
2024-10-26 @ 2:05 PM
Study NCT ID:
NCT04898088
Status:
COMPLETED
Last Update Posted:
2021-05-24
First Post:
2021-05-21
Brief Title:
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients
Sponsor:
SBÜ Dr Sadi Konuk Eğitim ve Araştırma Hastanesi
Organization:
SBÜ Dr Sadi Konuk Eğitim ve Araştırma Hastanesi
Study Overview
Official Title:
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients
Status:
COMPLETED
Status Verified Date:
2021-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
REPAIR
Brief Summary:
Our aim in this study is to determine the positive effect of stem cell therapy applied on critically ill patients with coronavirus infection on DNA repair genes
Patients diagnosed with COVID-19 infection are divided into two equal n30 groups Group-1n15 Patients in critically ill condition receiving conventional therapy Group-2 n15 Patients in critically ill condition receiving conventional therapy and systemically transplanted MSCs The DNA repair pathway will be examined as 11 genes in 5 different parts Investigated parameters
1 Base excision repair
2 Nucleotide excision repair
3 Recombinational repair
4 Mismatch repair
5 Direct reversal Investigated parameters broad biochemical analysis apoptosis clinical outcome and mortality rates
Patients diagnosed with COVID-19 infection are divided into two equal n30 groups Group-1n15 Patients in critically ill condition receiving conventional therapy Group-2 n15 Patients in critically ill condition receiving conventional therapy and systemically transplanted MSCs The DNA repair pathway will be examined as 11 genes in 5 different parts Investigated parameters
1 Base excision repair
2 Nucleotide excision repair
3 Recombinational repair
4 Mismatch repair
5 Direct reversal Investigated parameters broad biochemical analysis apoptosis clinical outcome and mortality rates
Detailed Description:
Our aim in this study is to determine the positive effect of stem cell therapy applied on critically ill patients with coronavirus infection on DNA repair genes
Patients diagnosed with COVID-19 infection are divided into two equal n30 groups Group-1n15 Patients in critically ill condition receiving conventional therapy Group-2 n15 Patients in critically ill condition receiving conventional therapy and systemically transplanted MSCs The DNA repair pathway will be examined as 11 genes in 5 different parts Investigated parameters
1 Base excision repair
2 Nucleotide excision repair
3 Recombinational repair
4 Mismatch repair
5 Direct reversal Investigated parameters broad biochemical analysis apoptosis clinical outcome and mortality rates
Patients diagnosed with COVID-19 infection are divided into two equal n30 groups Group-1n15 Patients in critically ill condition receiving conventional therapy Group-2 n15 Patients in critically ill condition receiving conventional therapy and systemically transplanted MSCs The DNA repair pathway will be examined as 11 genes in 5 different parts Investigated parameters
1 Base excision repair
2 Nucleotide excision repair
3 Recombinational repair
4 Mismatch repair
5 Direct reversal Investigated parameters broad biochemical analysis apoptosis clinical outcome and mortality rates
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None