Ignite Creation Date:
2024-05-05 @ 5:23 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00441714
Status:
WITHDRAWN
Last Update Posted:
2015-11-10
First Post:
2007-02-28
Brief Title:
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
Sponsor:
Radboud University Medical Center
Organization:
Radboud University Medical Center
Study Overview
Official Title:
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
Status:
WITHDRAWN
Status Verified Date:
2015-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
new insights have let us to expect marginal annexin targeting with a 10 minutes delay between reperfusion and administration of Annexin A5
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To adjust our forearm model for ischemia reperfusion injury in order to used it for assessment of ischemia reperfusion damage in elderly and patients
To test the effect of ischemic postconditioning on ischemia reperfusion injury in healthy volunteers using Annexin binding after repetitive handgripping
To test the effect of ischemic postconditioning on ischemia reperfusion injury in healthy volunteers using Annexin binding after repetitive handgripping
Detailed Description:
Recently ischemic postconditioning has been identified as a protective intervention against ischemia-reperfusion injury In animal studies the signalling pathway of this impressive protective phenomenon is very similar to ischemic preconditioning It opens a new avenue of post-reperfusion interventions with drugs that have been shown to mimic ischemic preconditioning Before we can study this phenomenon in our forearm ischemia-reperfusion model we need additional validating experiments The purpose of this study proposal is to provide these data
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None