Ignite Creation Date:
2024-05-06 @ 4:08 PM
Last Modification Date:
2024-10-26 @ 2:04 PM
Study NCT ID:
NCT04882488
Status:
RECRUITING
Last Update Posted:
2024-01-10
First Post:
2021-05-06
Brief Title:
Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis
Sponsor:
Heart and Diabetes Center North-Rhine Westfalia
Organization:
Heart and Diabetes Center North-Rhine Westfalia
Study Overview
Official Title:
Correlation of FFR and iFR With Cardiac PET Perfusion at Rest and Under Adenosine in the Evaluation of Intermediate Coronary Stenoses in Patients With Severe Aortic Valve Stenosis
Status:
RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TAVI PET
Brief Summary:
Aortic valve stenosis AS affects 2-7 of persons 65 years symptoms include angina and dyspnea dizziness and syncope Coincidence of coronary artery disease CAD also presenting with angina and dyspnea in patients with AS between 40 - 65 Angina in AS caused by significant reduction of coronary flow reserve CFR CFR is the ratio of maximal flow increase in the coronary vessel bed during maximal hyperaemia medically or exercise induced FFR fractional flow reserve use in patients with AS potentially invalid due to dysfunctional CFR leading to potential undertreatment of CAD in these patientsCFR disturbance in AS mainly due to myocardial overload causing concentric hypertrophy increased oxygen consumption and neurohormonal activation leading to increased vascular resistance Current studies are investigating the validity of FFR and iFR in AS patients Recent data demonstrate very good correlation between FFR and iFR derived values to PET myocardial perfusion imaging values in patients with no evidence of AS Our study aims to investigate the diagnostic performance of FFR and iFR in intermediate-grade coronary stenosis in patients with severe aortic valve disease and correlate FFR- and iFR derived values with those extracted from PET-perfusion Imaging
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None