Ignite Creation Date:
2024-05-06 @ 4:08 PM
Last Modification Date:
2024-10-26 @ 2:04 PM
Study NCT ID:
NCT04882020
Status:
UNKNOWN
Last Update Posted:
2021-05-11
First Post:
2021-05-05
Brief Title:
Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea
Sponsor:
Hospital de Clinicas de Porto Alegre
Organization:
Hospital de Clinicas de Porto Alegre
Study Overview
Official Title:
Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea
Status:
UNKNOWN
Status Verified Date:
2021-05
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aging process tends to promote an overall increase in inflammation compromising the immunologic system regulation sleepwakefulness pattern and neurocognitive performance In elders there is an increase in repetitive arousals during sleep secondary to breathing interruption by pharynx collapse generating a transient reduction in oxygen delivery to the brain known as obstructive sleep apnea This lack in oxygen supply results in an inflammatory process producing brain damage Some substances present in the blood seem to be associated to neurocognitive damage like S100β protein cortisol interleukin 1-β6 and TNF-α In the other way a substance called brain-derived neurotrophic factor BDNF enhances cognitive function and memory consolidation improvement
Detailed Description:
An intermittent hypoxia in obstructive sleep apnea induces the production of reactive oxygen species ROS oxidative damage and inflammation generating pro-inflammatory cytokines reactive gliosis and neuronal damage The increase in oxidative damage seems to be associated to age contributing to the progress of neurodegeneration Transient hypoxemia leads to autonomic excitation causing hyperactivity of the sympathetic nervous system SNS and activation of the hypothalamic-pituitary-adrenal HPA axis causing immunological changes and increased risk of damage to mental functions Night awakenings caused by OSA are associated with changes on the HPA axis resulting in increased serum cortisol levels The fluctuation in serum cortisol levels at night is intrinsically related to sleep and increases with advancing age BDNF is responsible for increasing the growth of neurites and synaptogenesis preventing programmed cell death in adults and is involved in stress responses on the HPA axis Low BDNF levels are associated to cognitive impairment less memory consolidation depression and OSA There is a positive correlation between levels of BDNF and cortisol related to physiological regulation of brain activities The increase in oxidative damage caused by intermittent hypoxia during obstructive sleep apnea increases serum levels of the s100β protein promoting reactive gliosis or astrogliosis being associated to depression in the elderly Obstructive sleep apnea syndrome is associated with development of cardiovascular and neurological diseases by activating pro-inflammatory pathways However in elderly individuals regardless of other specific pathologies they already have a pro-inflammatory state secondary to loss of regulation of the immune system
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None