Ignite Creation Date:
2024-05-06 @ 4:08 PM
Last Modification Date:
2024-10-26 @ 2:04 PM
Study NCT ID:
NCT04888910
Status:
UNKNOWN
Last Update Posted:
2021-05-21
First Post:
2021-05-11
Brief Title:
Novel Inflammatory Markers in Different Phenotypes of Severe Asthma
Sponsor:
University of Pisa
Organization:
University of Pisa
Study Overview
Official Title:
Novel Inflammatory Markers in Different Phenotypes of Severe Asthma
Status:
UNKNOWN
Status Verified Date:
2021-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Asthma is a highly prevalent chronic airway inflammatory disease characterized by airway hyper-responsiveness reversible airflow obstruction and increased mucus secretion involving large and small airways An emerging sub-phenotype of severe asthma is the late onset disease associated with nasal polyposis a frequent co-morbidity that significantly impacts lung function and symptom control On the basis of the infiltrate found in the sputum asthma can be divided into four distinct phenotypes eosinophilic neutrophilic mixed granulocytic and pauci-granulocytic The majority of patients with eosinophilic asthma are sensitive to corticosteroids and biological therapies targeting eosinophils anti-Interleukin IL-5 and anti-IL5R have been recently approved However it is known that some asthmatics particularly those who have severe disease and are resistant to corticosteroids have elevated neutrophil counts in the airway where they play a vital role in the exacerbation of the disease However the precise role of neutrophils in severe asthma and the mechanisms involved in neutrophil-induced tissue damage have not been clarified yet
The hypothesis of the study is that neutrophils and eosinophils can contribute to the severity of asthma by changing their phenotypes according to the airway environment Thus a better understanding of the roles of neutrophils and eosinophils in severe asthma may lead to the identification of novel biomarkers and the development of new therapeutic approaches in different phenotypes of severe asthma
The hypothesis of the study is that neutrophils and eosinophils can contribute to the severity of asthma by changing their phenotypes according to the airway environment Thus a better understanding of the roles of neutrophils and eosinophils in severe asthma may lead to the identification of novel biomarkers and the development of new therapeutic approaches in different phenotypes of severe asthma
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None