Ignite Creation Date:
2024-05-06 @ 4:08 PM
Last Modification Date:
2024-10-26 @ 2:04 PM
Study NCT ID:
NCT04889443
Status:
COMPLETED
Last Update Posted:
2024-03-13
First Post:
2021-05-07
Brief Title:
Spontaneous Healing of ARticular Cartilage SHARC
Sponsor:
Keele University
Organization:
Keele University
Study Overview
Official Title:
How do Cartilage Injuries Heal Naturally An Observational Study of Spontaneously Healing Cartilage Defects
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SHARC
Brief Summary:
SHARC is an observational study of cartilage patients who are treated with surgery that involves obtaining a harvest biopsy SHARC will study the natural healing process of the harvest biopsy site based on histological and biochemical analyses of repair tissue biopsies synovial fluid biomarkers medical imaging MRI and gait analysis
Detailed Description:
Osteoarthritis OA is a very common disease of the joints for which in the United Kingdom alone almost 9 million people have sought treatment This painful disease affects the cartilage and bone inside the joint Many factors are known to increase the risk of getting osteoarthritis or the rate at which it gets worse Very important among these factors is an injury or a defect of the cartilage It was believed for hundreds of years that cartilage once injured does not heal
Research from the past 10 years is now throwing doubt on this old certainty as researchers who took regular scans of volunteers over time noted that sometimes these defects come and then go A Japanese group of surgeons decided to look again after a year to see what had happened to these defects and noted that about half of them had got better Cartilage defects in human therefore can heal but nobody knows how this works
For many years our Center has helped patients who have knee cartilage damage by using the patients own cartilage cells to help repair areas of damaged cartilage This cell therapy starts by taking a piece of cartilage 10 mm from the patients knee and this created defect always heals after a year Thus our proposal is to use our cell therapy patients as a human experimental model of natural cartilage healing using a wide range of techniques including Magnetic Resonance Imaging MRI visual inspection of the joint itself during knee joint surgery examining biopsies of repair tissue down the microscope and measuring various kinds of molecules researchers think are important The information gathered from these tests will help bridge the gap in our understanding of the mechanisms involved in the cartilage tissue regeneration
Research from the past 10 years is now throwing doubt on this old certainty as researchers who took regular scans of volunteers over time noted that sometimes these defects come and then go A Japanese group of surgeons decided to look again after a year to see what had happened to these defects and noted that about half of them had got better Cartilage defects in human therefore can heal but nobody knows how this works
For many years our Center has helped patients who have knee cartilage damage by using the patients own cartilage cells to help repair areas of damaged cartilage This cell therapy starts by taking a piece of cartilage 10 mm from the patients knee and this created defect always heals after a year Thus our proposal is to use our cell therapy patients as a human experimental model of natural cartilage healing using a wide range of techniques including Magnetic Resonance Imaging MRI visual inspection of the joint itself during knee joint surgery examining biopsies of repair tissue down the microscope and measuring various kinds of molecules researchers think are important The information gathered from these tests will help bridge the gap in our understanding of the mechanisms involved in the cartilage tissue regeneration
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| MRN02706X1 | OTHER_GRANT | MRC UK | None |
| 18NW0291 | OTHER | None | None |
| 243678 | OTHER | None | None |