Ignite Creation Date:
2024-05-06 @ 4:07 PM
Last Modification Date:
2024-10-26 @ 2:04 PM
Study NCT ID:
NCT04878042
Status:
WITHDRAWN
Last Update Posted:
2022-11-23
First Post:
2021-05-04
Brief Title:
COVID-19 Infection Control Using H2O2 Mouth Wash and Nasal Spray
Sponsor:
EPISTATA
Organization:
EPISTATA
Study Overview
Official Title:
The Negativisation Rate of Positive PCR Swab Tests for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 After Treatment With Hydrogen Peroxide a Double-blind Placebo-controlled Randomised Trial
Status:
WITHDRAWN
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
No participants
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hydrogen peroxide is produced physiologically by oral bacteria and plays a significant role in the balance of oral microecology since it is an important antimicrobial agent In the epithelial cells the enzyme superoxide dismutase catalyzes a reaction leading from hydrogen peroxide to the ion superoxide The induced oxidative stress stimulates a local innate response via activation of the toll-like receptors and the NF-κB Those kinds of reactions are also activated by viral infections Virus-induced oxidative stress plays an important role in the regulation of the host immune system and the specific oxidant-sensitive pathway is one of the effective strategies against viral infections Therefore nosemouththroat washing with hydrogen peroxide may enhance those local innate responses to viral infections The investigators hypothesised that a treatment with a mouth wash and a nasal spray containing a diluted solution of hydrogen peroxide may accelerate the negativisation rate of a positive PCR swab test for SARS-CoV-2 COVID-19
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None