Ignite Creation Date:
2024-05-06 @ 4:06 PM
Last Modification Date:
2024-10-26 @ 2:03 PM
Study NCT ID:
NCT04873388
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2023-08-01
First Post:
2021-05-03
Brief Title:
Early Predictors of Prognostic Course in Patients With COVID-19 in Critical or Semi-intensive Area
Sponsor:
University of Turin Italy
Organization:
University of Turin Italy
Study Overview
Official Title:
Biomarkers and Early Predictors of Prognostic Course Response to Possible to Possible Treatments and Risk of Over-infection in Patients With COVID-19 Hospitalized in the Critical or Semi-intensive Area
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Although the recent literature is building a remarkable background to answer the many unknowns related to SARS-CoV-2 infection it is absolutely necessary to finalize every clinical effort to collect data that may be useful in a short time to improve our knowledge of SARS-CoV-2 infection Numerous biomarkers have been evaluated in the recent literature as being altered in patients with severe forms of COVID-19 Particularly in the critical care area the research of early predictors of mortality is essential for high-flow management of patients requiring invasive assisted ventilation and requiring invasive and non-invasive assisted ventilation hemodynamic support sometimes extracorporeal support Extracorporeal Membrane Oxygenation ECMO The coordinated study of different biomarkers in particular if combined with each other possibly even to constitute a possible score could guide the correct allocation of patients between hospital departments and the appropriate management in intensive care units appropriate management in intensive care units as well as providing an early prognostic indication prognostic indication The combination of these biomarkers with routine clinical and laboratory data may further provide valuable information about their use in acute care and as progressive acute and as progressive monitoring over time
Regarding the data of interest on the clinical trend the evaluation of the respiratory support modalities from the administration of oxygen therapy by nasal cannulae or Venturi mask or by high flow system - High Flow Nasal Cannula HFNC to CPAP support or by non-invasive or invasive ventilation appears of particular importance
Therefore the present study will be conducted in sub-intensive as well as intensive care units in order to evaluate different types of patients and their possible evolution over time
The comparison between the populations belonging to different areas of intensity of care will be able to describe the different populations Data analysis will allow an evaluation of possible risk factors and prognostic determinants of the severity of the disease and its infectious complications
Regarding the data of interest on the clinical trend the evaluation of the respiratory support modalities from the administration of oxygen therapy by nasal cannulae or Venturi mask or by high flow system - High Flow Nasal Cannula HFNC to CPAP support or by non-invasive or invasive ventilation appears of particular importance
Therefore the present study will be conducted in sub-intensive as well as intensive care units in order to evaluate different types of patients and their possible evolution over time
The comparison between the populations belonging to different areas of intensity of care will be able to describe the different populations Data analysis will allow an evaluation of possible risk factors and prognostic determinants of the severity of the disease and its infectious complications
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None