Ignite Creation Date:
2024-05-05 @ 5:22 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00446628
Status:
COMPLETED
Last Update Posted:
2016-01-27
First Post:
2007-03-12
Brief Title:
Project to Investigate Ways to Reduce the Spread of Influenza in Schools and Households With Children
Sponsor:
Kiren Mitruka
Organization:
Centers for Disease Control and Prevention
Study Overview
Official Title:
Pittsburgh Influenza Prevention Project
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PIPP
Brief Summary:
The purpose of this study is to understand the spread of influenza flu in schools and households with elementary K-5 school children and develop ways to reduce the flu using non-pharmaceutical means
Detailed Description:
Pandemic influenza threatens to cause substantial disability death and societal disruption and to overwhelm health care systems in the United States and around the world Because effective vaccines may not be available during the initial months of a pandemic and because anti-viral medication is both largely ineffective and in short supply non-pharmacological personal protection and behavioral changes may be the only means to combat the epidemic In our computational modeling work through the Models of Infectious Disease Agent Study network we have shown the potential value of multiple targeted and layered non-pharmacological interventions in blunting the peak impact and slowing of a pandemic Nature in press
Phase 1 of the project will be a pilot study in two elementary schools in the City of Pittsburgh The project has already obtained agreement to collaborate from the Pittsburgh Public School System and we have assembled a multi-disciplinary team of epidemiologists systems analysts modelers community and minority health workers and virologists to implement the project Phase one was in 2 schools
Phase 2 will be similar to Phase 1 with the addition of additional schools and application of a hygiene intervention to selected schools and families Phase 2 is in 10 schools with 3800 students
Specific aims year 02
Primary
1 Measure the effectiveness of non-pharmaceutical interventions NPIs in reducing influenza rates among enrolled students in the intervention and control schools when influenza is known to be circulating in the community Note Enrolled for purposes of PIPP will indicate students who present with ILI consent to participate and are tested for influenza during the flu season Secondary School-Based
2 Measure number of absentees and determine the reason for absence by using a school based absentee illness surveillance system prior to and through the end of influenza season
3 Measure the effectiveness of NPIs in reducing absenteeism from all causes including illnessURI illnessILI illnessother and illnessGI through the end of influenza season
4 Measure the effectiveness of NPIs in reducing secondary spread of ILI within classrooms of participating schools
5 Assess adoption of NPI behaviors and activities in classrooms of intervention schools
Secondary Home-Based
6 Measure the effectiveness of NPIs in reducing secondary cases of ILI within families of enrolled school children with influenza
7 Assess adherence of families of enrolled school children with influenza to isolation-related NPI behaviors and activities
Tertiary
8 Measure correlation between rapid flu testing and PCR testing for influenza
9 Collect and archive influenza specimens for future molecular epidemiological studies
10 Contribute a sample of influenza-positive specimens to the CDC for national influenza surveillance purposes
Phase 1 of the project will be a pilot study in two elementary schools in the City of Pittsburgh The project has already obtained agreement to collaborate from the Pittsburgh Public School System and we have assembled a multi-disciplinary team of epidemiologists systems analysts modelers community and minority health workers and virologists to implement the project Phase one was in 2 schools
Phase 2 will be similar to Phase 1 with the addition of additional schools and application of a hygiene intervention to selected schools and families Phase 2 is in 10 schools with 3800 students
Specific aims year 02
Primary
1 Measure the effectiveness of non-pharmaceutical interventions NPIs in reducing influenza rates among enrolled students in the intervention and control schools when influenza is known to be circulating in the community Note Enrolled for purposes of PIPP will indicate students who present with ILI consent to participate and are tested for influenza during the flu season Secondary School-Based
2 Measure number of absentees and determine the reason for absence by using a school based absentee illness surveillance system prior to and through the end of influenza season
3 Measure the effectiveness of NPIs in reducing absenteeism from all causes including illnessURI illnessILI illnessother and illnessGI through the end of influenza season
4 Measure the effectiveness of NPIs in reducing secondary spread of ILI within classrooms of participating schools
5 Assess adoption of NPI behaviors and activities in classrooms of intervention schools
Secondary Home-Based
6 Measure the effectiveness of NPIs in reducing secondary cases of ILI within families of enrolled school children with influenza
7 Assess adherence of families of enrolled school children with influenza to isolation-related NPI behaviors and activities
Tertiary
8 Measure correlation between rapid flu testing and PCR testing for influenza
9 Collect and archive influenza specimens for future molecular epidemiological studies
10 Contribute a sample of influenza-positive specimens to the CDC for national influenza surveillance purposes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CDC-U01 CI000435-01 | OTHER_GRANT | CDC | None |