Ignite Creation Date:
2024-05-06 @ 4:05 PM
Last Modification Date:
2024-10-26 @ 2:03 PM
Study NCT ID:
NCT04867759
Status:
RECRUITING
Last Update Posted:
2024-02-28
First Post:
2021-04-29
Brief Title:
Uterine Natural Killer uNK Cell Expression in Patients With Repeated ICSI Failures A Multicenter Cohort Study
Sponsor:
Tanta University
Organization:
Tanta University
Study Overview
Official Title:
Uterine Natural Killer uNK Cell Expression in Patients With Repeated ICSI Failures A Multicenter Cohort Study
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
UNK
Brief Summary:
uterine NK uNK cells are characterized by a high expression of CD56 CD56brihgt lack of CD16 expression high secretion of cytokines and rather low cytotoxic activity It has been shown that uNK cells increase in number during the late secretory phase and during early pregnancy This study was designed to assess the possible role of uNK cells in repeated ICSI failure
Detailed Description:
For occurrence of the window of implantation the endometrium must proliferate increase in thickness then after ovulation adequately respond to progesterone and become receptive Ultrasound examination of the thickness and appearance of the endometrium is an easily performed means of assessing morphological changes occurring in the endometrium during the follicular phase and is thus used as a measure to predict successful implantation Indeed several studies have reported a strong association between endometrial thickness and successful implantation However others failed to confirm such an association The minimal adequate endometrial thickness for successful implantation as measured in the late proliferative phase varies between studies with a range of 6-8 mm However although rare some investigators have reported successful implantation in an endometrium of no more than 5 mm thickness
Uterine NK cell testing can only be done via an endometrial biopsy Uterine natural killer cells never come into direct contact with the fetal cells-they only have direct access to placental cellsThe biopsy is performed on day 21 of your menstrual cycle when the NK cell count is at its highest The procedure is done at outpatient clinics and results take about two weeks to receive If your NK cell activity reading is greater than 14 on day 21 biopsy then diagnosed with high levels of NK cell activity
Uterine NK cell testing can only be done via an endometrial biopsy Uterine natural killer cells never come into direct contact with the fetal cells-they only have direct access to placental cellsThe biopsy is performed on day 21 of your menstrual cycle when the NK cell count is at its highest The procedure is done at outpatient clinics and results take about two weeks to receive If your NK cell activity reading is greater than 14 on day 21 biopsy then diagnosed with high levels of NK cell activity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None