Ignite Creation Date:
2024-05-05 @ 5:22 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00448162
Status:
SUSPENDED
Last Update Posted:
2011-03-31
First Post:
2007-03-15
Brief Title:
The Chinese Mutation Hotspot of ENaC Causing Liddles Syndrome and the Association of ENaC Variations and Hypertension
Sponsor:
Peking Union Medical College
Organization:
Peking Union Medical College
Study Overview
Official Title:
None
Status:
SUSPENDED
Status Verified Date:
2009-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
no enough fund
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The variations of ENaC have an impact on the degradation of epithelial sodium channels and sodium reabsorption and thus are associated with hypertension and hypokalemia
Liddles syndrome is a rare monogenic form of autosomal-dominant hypertension caused by truncating or missense mutations in the C-termini of epithelial sodium channel β- or γ-subunit encoded by SCNN1B or SCNN1G Our purpose is to determine the hotspot of mutation causing Chinese Liddles syndrome
The second purpose is to determine wether the polymorphisms of ENaC are associated with hypertension in Chinese Some polymorphisms of ENaC associated with hypertension may be genetic risk factors for Chinese hypertension
Liddles syndrome is a rare monogenic form of autosomal-dominant hypertension caused by truncating or missense mutations in the C-termini of epithelial sodium channel β- or γ-subunit encoded by SCNN1B or SCNN1G Our purpose is to determine the hotspot of mutation causing Chinese Liddles syndrome
The second purpose is to determine wether the polymorphisms of ENaC are associated with hypertension in Chinese Some polymorphisms of ENaC associated with hypertension may be genetic risk factors for Chinese hypertension
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None