Ignite Creation Date:
2024-05-06 @ 4:01 PM
Last Modification Date:
2024-10-26 @ 2:02 PM
Study NCT ID:
NCT04845165
Status:
UNKNOWN
Last Update Posted:
2022-06-27
First Post:
2021-04-13
Brief Title:
Study of Cortisol Metabolism in Familial Partial Lipodystrophy Type 2
Sponsor:
University Hospital Lille
Organization:
University Hospital Lille
Study Overview
Official Title:
Study of Cortisol Metabolism in Familial Partial Lipodystrophy Type 2
Status:
UNKNOWN
Status Verified Date:
2022-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LIPOCORT
Brief Summary:
Familial partial lipodystrophic syndromes are characterized by an increase in visceral adipose tissue and an atrophy of subcutaneous adipose tissue They are associated with a severe metabolic syndrome especially when linked to the mutation of the R482 codon of the LMNA gene Familial partial lipodystrophy type 2 FPL2 Data in lipodystrophy induced by antiretroviral therapy of HIV suggests an increase in the activity of 11β-hydroxysteroid dehydrogenase type 1 11bHSD1 This enzyme reactivates cortisone in cortisol in adipose tissues and liver and has associated to obesity and type 2 diabetes mellitus Hence the hypothesis is that in patients suffering from FPL2 with the R482 codon mutation of the LMNA gene there is an increase in the activity of HSD11B1 which could participate to the metabolic phenotype of the disease
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2020-A03167-32 | OTHER | ID-RCB numberANSM | None |