Ignite Creation Date:
2024-05-06 @ 4:00 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04832477
Status:
RECRUITING
Last Update Posted:
2024-05-08
First Post:
2021-03-29
Brief Title:
Assessing the PrEP Care Cascade Among Black Men and Transwomen in the Southeastern US
Sponsor:
University of Connecticut
Organization:
University of Connecticut
Study Overview
Official Title:
PrEP Connected Study
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The proposed research aims to assess the multiple forms and paths of stigma and substance use as they relate to pre-exposure prophylaxis PrEP use for HIV prevention How stigma and an evolving public health landscape impact PrEP use among Black sexual minorit men who use substances is unknown The current application focuses on addressing critical and novel questions to improving the essential building blocks of biomedical prevention approaches by providing crucial information for enhancing interventions to lower HIV prevalence among substance using Black sexual minority men
Detailed Description:
HIV incidence among Black men who have sex with men BMSM in the southeastern United States is one of the highest in the world Our research team has conducted studies with BMSM in Atlanta that have demonstrated 35 HIV prevalence and over 5 annual HIV incidence Although PrEP is highly effective for preventing HIV transmission it is not reaching BMSM The failures in our ability to engage BMSM in PrEP use are highly problematic given the alarming rates of HIV transmission among this group Of particular concern is the impact of substance use as a barrier in PrEP linkage uptake adherence and persistence Substance use is common among BMSM in our study with 43 n204474 reporting recent substance use Further complicating PrEP use is the potential impact of COVID-19 on health care access health care infrastructure and sex behavior The need to better understand PrEP use in the context of our new health care landscape is critical to making advances in PrEP use At this point assessing how substance use impacts PrEP use is challenging because PrEP implementation is so low among this group The current study aims to provide substance using BMSM with evidence-based PrEP engagement counseling to address barriers to accessing PrEP not for intervention testing but for facilitating PrEP use and to assess the multiple forms and paths of stigma and substance use as they relate to PrEP linkage uptake adherence and persistence The investigators propose using the HIV Stigma Framework as a conceptual model for investigating the intersecting pathways of stigma drivers and stigma mechanisms as they relate to PrEP use among substance using BMSM Aim 1 Enroll a prospective cohort of N500 BMSM who test HIV negative and test substance use positive on toxicology testing and provide evidence-based PrEP engagement counseling to facilitate access to PrEP care Aim 2 Conduct psychosocial and health care access assessments every 2-months for 18-months and conduct HIVSTI testing and dried blood spot testing for TFV-DP every 3-months for 18-months Aim 3 Using data collected from Aims 1 and 2 model stigma pathways of advancing and reverting along the PrEP cascade ie linkage uptake adherence persistence with these pathways mediated by health care access and moderated by substance use Achieving the aims will provide critical insight for translating and adapting interventions to enhance potency and durability for individuals at exceedingly elevated risk for HIV
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None