Ignite Creation Date:
2024-05-06 @ 4:00 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04833179
Status:
NOT_YET_RECRUITING
Last Update Posted:
2021-04-06
First Post:
2021-03-01
Brief Title:
Fecal Transplant for Alopecia Areata
Sponsor:
Tel-Aviv Sourasky Medical Center
Organization:
Tel-Aviv Sourasky Medical Center
Study Overview
Official Title:
Fecal Transplant for Alopecia Areata
Status:
NOT_YET_RECRUITING
Status Verified Date:
2021-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
the investigators intend to analyze the microbiome in the diseased areas healthy skin and fecal samples In addition the investigators plan to evaluate how the fecal transplant can influence the severity of the disease and hair growth all in hope that fecal transplant can help to treat or even cure AA This may help dermatologists in the future and expand the treatment options for AA
Detailed Description:
Alopecia areata AA is a common autoimmune disease that triggers non scarring hair loss in different severities Usually the hair loss will be contained to the scalp and or beard but in some cases there will be total hair loss from the entire scalp alopecia totalis or complete loss of all body facial and scalp hair alopecia universalis
AA is an autoimmune disease that produces an inflammation surrounding the hair follicles this leads to temporary hair loss In cases the disease become chronic the immune system attack may lead to a permanent hair loss This common hair disease has a significant impact on the patients quality of life it can cause impairment on the patients confidence self-esteem lead to depression and more
Lately two patients with AA and clostridium difficile infection were treated with fecal transplantation for their infection Rebello et al 2017 After the transplant a significant improvement was notice in hair growth These 2 cases raised the option that a fecal transplant may have an additional effect on the autoimmune reaction against the hair follicle in AA
the investigators intend to analyze the microbiome in the diseased areas healthy skin and fecal samples In addition the investigators plan to evaluate how the fecal transplant can influence the severity of the disease and hair growth all in hope that fecal transplant can help to treat or even cure AA This may help dermatologists in the future and expand the treatment options for AA
AA is an autoimmune disease that produces an inflammation surrounding the hair follicles this leads to temporary hair loss In cases the disease become chronic the immune system attack may lead to a permanent hair loss This common hair disease has a significant impact on the patients quality of life it can cause impairment on the patients confidence self-esteem lead to depression and more
Lately two patients with AA and clostridium difficile infection were treated with fecal transplantation for their infection Rebello et al 2017 After the transplant a significant improvement was notice in hair growth These 2 cases raised the option that a fecal transplant may have an additional effect on the autoimmune reaction against the hair follicle in AA
the investigators intend to analyze the microbiome in the diseased areas healthy skin and fecal samples In addition the investigators plan to evaluate how the fecal transplant can influence the severity of the disease and hair growth all in hope that fecal transplant can help to treat or even cure AA This may help dermatologists in the future and expand the treatment options for AA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None