Ignite Creation Date:
2024-05-05 @ 5:21 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00438074
Status:
RECRUITING
Last Update Posted:
2024-02-09
First Post:
2007-02-20
Brief Title:
A Pilot Study To Evaluate the Effectiveness of Pulsed Time-Domain Optical Spectroscopy for Monitoring the Responses in Neoadjuvant Treatments of Locally-Advanced Breast Cancer
Sponsor:
Sunnybrook Health Sciences Centre
Organization:
Sunnybrook Health Sciences Centre
Study Overview
Official Title:
A Pilot Study To Evaluate the Effectiveness of Pulsed Time-Domain Optical Spectroscopy for Monitoring the Responses in Neoadjuvant Treatments of Locally-Advanced Breast Cancer
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate optical tissue characteristics as a function of neoadjuvant breast cancer treatment Our objective in this pilot study will be to identify diffuse optical spectroscopy parameters that change with treatment and that may correlate with pathological response The ultimate goal is to use such parameters ultrasound as an early predictor of pathological partial or complete response in women with locally advanced breast cancer receiving treatment with neoadjuvant treatments such as chemotherapy or neoadjuvant combined modality chemotherapy and radiotherapy
Detailed Description:
Breast cancer is the most common malignancy for females in North America Around 5-15 of the estimated 200000 new cases diagnosed each year will present with locally advanced breast cancer LABC The definition of what constitutes LABC is complex and variable Clinically these tumours are usually considered to be those greater than 5cm in size andor extend beyond the breast tissue into the surrounding skin or muscle Patients with matted axillary lymph nodes N2 or internal mammary nodes N3 or ipsilateral supraclavicular lymph node involvement are also considered to have LABC In view of the extensive nature of these tumours at presentation women with LABC have a poor outcome in terms of both local and systemic recurrence Standard treatment for these patients is usually neoadjuvant systemic chemotherapy or less frequently endocrine therapy followed by surgery and radiotherapy Patients who have hormone receptor positive tumours will then receive endocrine therapy With the use of multidisciplinary therapy 10-year disease free survival rates of 50 for Stage IIIA and 33 for Stage IIIB disease have been reported
The impetus for undertaking this study is that we are searching for imaging methods that could potentially serve as surrogate indicators of pathological response One such modality that we wish to investigate as it may be ultimately useful in this patient population is diffuse optical spectrometry This modality depends on differentiating oxygenated from deoxygenated tissue but is also sensitive to other changes in tissue characteristics It has been used before in proof-of-principle studies differentiating benign from malignant disease but we hypothesize that it may be more useful in terms of monitoring tumour responses to treatment This is a non-invasive imaging modality that is easy to administer and relatively inexpensive
The impetus for undertaking this study is that we are searching for imaging methods that could potentially serve as surrogate indicators of pathological response One such modality that we wish to investigate as it may be ultimately useful in this patient population is diffuse optical spectrometry This modality depends on differentiating oxygenated from deoxygenated tissue but is also sensitive to other changes in tissue characteristics It has been used before in proof-of-principle studies differentiating benign from malignant disease but we hypothesize that it may be more useful in terms of monitoring tumour responses to treatment This is a non-invasive imaging modality that is easy to administer and relatively inexpensive
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None