Ignite Creation Date:
2024-05-06 @ 4:00 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04838574
Status:
RECRUITING
Last Update Posted:
2023-04-13
First Post:
2021-03-19
Brief Title:
Post-Chikungunya Rheumatism - Rheumatology Follow-up of Patients After 15 Years
Sponsor:
Centre Hospitalier Universitaire de la Réunion
Organization:
Centre Hospitalier Universitaire de la Réunion
Study Overview
Official Title:
Post-Chikungunya Rheumatism - Rheumatology Follow-up of Patients After 15 Years
Status:
RECRUITING
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ChikRhuma15
Brief Summary:
Reunion Island was struck by a severe Chikungunya outbreak in 2005-2006 Three hundred and seven Chikungunya patients were evaluated by 4 rheumatologists 2 months after the initial infection RHUMATOCHIK study Eighty-three percents still reported joint pain and 43 joint swelling in telephone interviews after 32 months Bouquillard et al 2018 The primary objective of the present study is to assess and classify precisely persistent Chi-related joint diseases after 15 years in a second rheumatology examination
Detailed Description:
Reunion Island was struck in 2005-2006 by the most severe Chikungunya outbreak seroprevalence 38 Gérardin et al 2013 in a developed but previously non-immunized country providing an unique opportunity for studying Chikungunya-related joint symptoms and their long-term evolution In a previous study the investigators demonstrated that at least 1773 patients initially classified as Chikungunya-related inflammatory joint diseases after 40 months still suffered from inflammatory joint symptoms fullfilling validated classification criteria after 13 years Guillot et al 2020 However in this monocentric study the investigators did not consider the full spectrum of Chikungunya-related rheumatic diseases the population was not fully representative and the sample size was not sufficient to perform statistical analyses nor identify poor prognosis markers In the RHUMATOCHIK cohort study 307 patients were evaluated by 4 rheumatologists 2 months after the infection 83 and 43 reported persistent joint pain and joint swelling respectively after 32 months in potentially biased telephone interviews Bouquillard et al 2018
In this context the present study aims at performing a systematic clinical rheumatologic re-evaluation of the RHUMATOCHIK patients after 15 years in order to precisely describe and classify the full spectrum of persistent Chikungunya-related joint diseases in a larger population
After a telephone interview and screening questionnaire these patients will be clinically re-evaluated by a second rheumatologist in a multicenter transversal follow-up study
In this context the present study aims at performing a systematic clinical rheumatologic re-evaluation of the RHUMATOCHIK patients after 15 years in order to precisely describe and classify the full spectrum of persistent Chikungunya-related joint diseases in a larger population
After a telephone interview and screening questionnaire these patients will be clinically re-evaluated by a second rheumatologist in a multicenter transversal follow-up study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None