Ignite Creation Date:
2024-05-06 @ 4:00 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04831359
Status:
UNKNOWN
Last Update Posted:
2021-04-05
First Post:
2021-03-29
Brief Title:
Tissue Doppler Assessment of Right Ventricle Function in Pediatrics Underwent Chemotherapy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Tissue Doppler Assessment of Right Ventricular Function in Newly Diagnosed Pediatric Cancer Patients Underwent Chemotherapy in South Egypt Cancer Institute
Status:
UNKNOWN
Status Verified Date:
2021-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tissue Doppler assessment of right ventricular function in newly diagnosed pediatric cancer patients underwent chemotherapy in South Egypt Cancer Institute
Detailed Description:
The incidence of cancer is always increasing and it is predicted that the incidence will increase to 45 by 20301 The introduction of new chemotherapeutic agents significantly improved survival but also revealed large spectrum of cardiotoxicity manifestations 2 There are many factors that increase the risk of cardiotoxicity caused by different chemotherapeutic agents such as type of chemotherapy cumulative dose concomitant or previous radiotherapy and comorbidities 3 Chemotherapeutic regimens which contain anthracyclines cyclophosphamide fluorouracil cisplatin taxanes and trastuzumab cause early and late cardiotoxicity 4
The majority of published studies are focused on left ventricle dysfunction in patients receiving cardiotoxic chemotherapy However the right ventricle has been ignored for a long time and a little attention has been directed to show the effect of chemotherapy on right ventricle function Right ventricle dysfunction is associated with increased morbidity and mortality in many cardiovascular diseases 5 The structure of cardiomyocytes and blood supply between the left and right ventricles are similar Given the smaller mass and fewer myofibrils of right ventricle chemotherapy may theoretically cause a more significant impact on it 6
The right ventricle has a complex geometric shape which includes smooth muscular inflow outflow and a trabecular apical region so echocardiographic assessment of right ventricle is difficult 7
M-mode echocardiography two-dimensional echocardiography conventional Doppler echocardiography and myocardial Doppler tissue imaging are all used to evaluate right ventricular function and provide accurate prognostic information especially when used in combination
The majority of published studies are focused on left ventricle dysfunction in patients receiving cardiotoxic chemotherapy However the right ventricle has been ignored for a long time and a little attention has been directed to show the effect of chemotherapy on right ventricle function Right ventricle dysfunction is associated with increased morbidity and mortality in many cardiovascular diseases 5 The structure of cardiomyocytes and blood supply between the left and right ventricles are similar Given the smaller mass and fewer myofibrils of right ventricle chemotherapy may theoretically cause a more significant impact on it 6
The right ventricle has a complex geometric shape which includes smooth muscular inflow outflow and a trabecular apical region so echocardiographic assessment of right ventricle is difficult 7
M-mode echocardiography two-dimensional echocardiography conventional Doppler echocardiography and myocardial Doppler tissue imaging are all used to evaluate right ventricular function and provide accurate prognostic information especially when used in combination
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None