Ignite Creation Date:
2024-05-06 @ 4:00 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04837391
Status:
UNKNOWN
Last Update Posted:
2021-04-08
First Post:
2021-04-01
Brief Title:
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients POCD
Sponsor:
Istanbul University
Organization:
Istanbul University
Study Overview
Official Title:
Evaluation of the Relationship Between Postoperative Cognitive Dysfunction and Brain Injury Biomarkers In Geriatric Urologic Oncology Patients
Status:
UNKNOWN
Status Verified Date:
2021-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
POCD
Brief Summary:
Postoperative cognitive changes are more common in elderly patients which can result in poor quality of life loss of workforce disability early retirement physical-social dependence increased health care cost and premature mortality Postoperative cognitive complications are also quite common in extensive oncological surgeries In this study our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction POCD in geriatric urologic oncology patients with brain injury and inflammatory markers S100 β neuron specific enolase NSE interleukin 6 IL-6 and high mobility group box-1 HMGB-1 protein
Detailed Description:
The incidence of POCD changes by age group type of surgery testing neuropsychological tests timing of tests and the method used for diagnosis In non-cardiac surgery over the age of 60 the incidence of POCD was 26 in the postoperative 1st week and 10 in the postoperative 3rd month Although old age is an important risk factor POCD incidence of up to 366 has been reported in a younger period Major cancer surgery is an important risk factor for development of POCD
Numerous biomarkers such as S100β NSE Human IL-6 HMGB-1 protein have been evaluated in studies to determine the diagnosis prognosis stage and treatment of POCD
In this study our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction POCD in geriatric urologic oncology patients with brain injury and inflammatory markers S100β NSE Human IL-6 and HMGB-1 proteinThe hypothesis of our study is that postoperative brain injury and inflammatory markers S100β NSE Human IL-6 and HMGB-1 protein will be higher in patients who develop POCD compared to patients who do not develop POCD in geriatric urologic oncology surgery
Numerous biomarkers such as S100β NSE Human IL-6 HMGB-1 protein have been evaluated in studies to determine the diagnosis prognosis stage and treatment of POCD
In this study our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction POCD in geriatric urologic oncology patients with brain injury and inflammatory markers S100β NSE Human IL-6 and HMGB-1 proteinThe hypothesis of our study is that postoperative brain injury and inflammatory markers S100β NSE Human IL-6 and HMGB-1 protein will be higher in patients who develop POCD compared to patients who do not develop POCD in geriatric urologic oncology surgery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None