Ignite Creation Date:
2024-05-06 @ 3:59 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04832009
Status:
RECRUITING
Last Update Posted:
2022-05-16
First Post:
2021-03-31
Brief Title:
Reversing Glucose and Lipid-mediated Vascular Dysfunction
Sponsor:
University of Kansas Medical Center
Organization:
University of Kansas Medical Center
Study Overview
Official Title:
Reversing Glucose and Lipid-mediated Vascular Dysfunction REGAL
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
REGAL
Brief Summary:
The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat lipids in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure
Detailed Description:
Hypertension obesity and insulin resistance are associated with elevated muscle sympathetic nerve activity MSNA which is important for blood pressure regulation The measurement of MSNA is safely performed in humans using the microneurographic technique that involves recording sympathetic nerve activity projecting to skeletal muscle using a small microelectrode at the peroneal nerve near the knee
The health of your blood vessels will be tested in this study in addition to the activity of the nerves that control the blood vessels The function of the nerves and blood vessels can be diminished by high blood glucose and lipids and we will test the ability of a well-known antioxidant ascorbic acid vitamin C to restore the function of the nerves and blood vessels
The health of your blood vessels will be tested in this study in addition to the activity of the nerves that control the blood vessels The function of the nerves and blood vessels can be diminished by high blood glucose and lipids and we will test the ability of a well-known antioxidant ascorbic acid vitamin C to restore the function of the nerves and blood vessels
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None