Ignite Creation Date:
2024-05-06 @ 3:59 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04837495
Status:
COMPLETED
Last Update Posted:
2023-12-05
First Post:
2021-04-06
Brief Title:
Stellate Ganglion Block in Control of Arrhythmia in Laparoscopic Cholecystectomy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Stellate Ganglion Block Efficacy in Control of Arrhythmia and Cardiovascular Changes in Addition to Postoperative Analgesia in Laparoscopic Cholecystectomy
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
During Laparoscopic cholecystectomy carbon dioxide CO2 pneumoperitoneal laparoscopic surgery CO2-pneumoperitoneum activates the sympathoadrenomedullary system to increase the release of catecholamines such as epinephrine E norepinephrine NE and dopamine DA During stress E and NE are secreted by the adrenal medulla into blood circulation to promote glycogenolysis to increase blood glucose speed up lipolysis and accelerate heartbeats Stellate g anglion block SGB reters to the blockade of sympathetic nerves including the large area covered by middle cervical vertebral arterial stellate ganglions and ther pre- and post- ganglions SGB affects both peripheral and central nervous systems In the peripheral system the sympathetic pre- and post-ganglionic fibers in the innervated areas of stellate ganglion are affected Therefore the control of vascular dilatation and constriction muscular movement bronchial smooth muscle relaxation and contraction and pain conduction by sympathetic nerves is inhibited In the central nervous system the hypothalamus is mainly involved in the regulation of systemic autonomic nervous immune and endocrine systems and to maintain homeostasis
CO2-pneumoperitoneum causes severe stress-related homeostatic disorders including arrhythmia and blood pressure changes This study will examine the effects of stellate ganglion block SGB on hemodynamics and stress response in patients undergoing CO-pneumoperitoneal surgery
CO2-pneumoperitoneum causes severe stress-related homeostatic disorders including arrhythmia and blood pressure changes This study will examine the effects of stellate ganglion block SGB on hemodynamics and stress response in patients undergoing CO-pneumoperitoneal surgery
Detailed Description:
Laparoscopic surgery is being increasingly recognized for its advantages of minimal invasiveness mild postoperative pain short length of hospitalization and rapid recovery and is widely used in general surgery obstetrics gynecology and urology Laparoscopic cholecystectomy LC has become the gold standard for surgically treating benign diseases of the gallbladder
During carbon dioxide CO2 pneumoperitoneal laparoscopic surgery CO2-pneumoperitoneum activates the sympathoadrenomedullary system to increase the release of catecholamines such as epinephrine E norepinephrine NE and dopamine DA During stress E and NE are secreted by the adrenal medulla into blood circulation to promote glycogenolysis to increase blood glucose speed up lipolysis and accelerate heartbeats Stellate g anglion block SGB reters to the blockade of sympathetic nerves including the large area covered by middle cervical vertebral arterial stellate ganglions and ther pre- and post- ganglions SGB affects both peripheral and central nervous systems In the peripheral system the sympathetic pre- and post-ganglionic fibers in the innervated areas of stellate ganglion are affected Therefore the control of vascular dilatation and constriction muscular movement bronchial smooth muscle relaxation and contraction and pain conduction by sympathetic nerves is inhibited In the central nervous system the hypothalamus is mainly involved in the regulation of systemic autonomic nervous immune and endocrine systems and to maintain homeostasis
CO2-pneumoperitoneum causes severe stress-related homeostatic disorders including arrhythmia and blood pressure changes This study will examine the effects of stellate ganglion block SGB on hemodynamics and stress response in patients undergoing CO-pneumoperitoneal surgery
During carbon dioxide CO2 pneumoperitoneal laparoscopic surgery CO2-pneumoperitoneum activates the sympathoadrenomedullary system to increase the release of catecholamines such as epinephrine E norepinephrine NE and dopamine DA During stress E and NE are secreted by the adrenal medulla into blood circulation to promote glycogenolysis to increase blood glucose speed up lipolysis and accelerate heartbeats Stellate g anglion block SGB reters to the blockade of sympathetic nerves including the large area covered by middle cervical vertebral arterial stellate ganglions and ther pre- and post- ganglions SGB affects both peripheral and central nervous systems In the peripheral system the sympathetic pre- and post-ganglionic fibers in the innervated areas of stellate ganglion are affected Therefore the control of vascular dilatation and constriction muscular movement bronchial smooth muscle relaxation and contraction and pain conduction by sympathetic nerves is inhibited In the central nervous system the hypothalamus is mainly involved in the regulation of systemic autonomic nervous immune and endocrine systems and to maintain homeostasis
CO2-pneumoperitoneum causes severe stress-related homeostatic disorders including arrhythmia and blood pressure changes This study will examine the effects of stellate ganglion block SGB on hemodynamics and stress response in patients undergoing CO-pneumoperitoneal surgery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None