Ignite Creation Date:
2024-05-06 @ 3:59 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04833439
Status:
COMPLETED
Last Update Posted:
2022-07-27
First Post:
2021-03-30
Brief Title:
The Effect of a Fasting MimickINg Diet on the Immune System
Sponsor:
Leiden University Medical Center
Organization:
Leiden University Medical Center
Study Overview
Official Title:
The Effect of a Fasting MimickINg Diet on the Immune System an Exploratory Study
Status:
COMPLETED
Status Verified Date:
2022-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FIND
Brief Summary:
Fasting or a Fasting Mimicking diet FMD can lower blood concentration of glucose and IGF1 Since cancer cells rely mostly on a glucose-based metabolism FMD renders cancer cells more vulnerable to chemotherapy thereby enhancing therapeutic efficacy This process is known as differential stress sensitization DSS Another response to nutritional stress by fasting is known as differential stress resistance DSR DSR is a state in which healthy cells rather focus resources on protection and internal repair which can result in reduced chemotherapeutic toxicity Recent preclinical studies found that fasting or FMD not only aids healthy cell protection but also has the potential to benefit effector T-cells and could thereby improve antitumor immunity However in most oncotherapeutic clinical trials investigating the addition of a fasting regimen other factors such as chemotherapy surgery and additional medication affect the immune system as well That is why this explorative study conducted in healthy subjects might be more suitable to investigate the immunological alterations upon FMD more specifically This exploratory study aims to identify immunological alterations by using extensive immunoprofiling before and after three days of FMD in healthy subjects as well as investigate possible side effects of FMD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P21017 | OTHER | LUMC | None |