Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001496
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer
Status:
COMPLETED
Status Verified Date:
2001-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Women who are at high risk for breast cancer either because of linkage to high risk breast and ovarian cancer families or because of a carcinoma in the opposite breast will be studied Women will have a physical examination and mammography to ensure that no breast abnormalities are present Eligible women will undergo biopsy of the breast to obtain normal breast tissue Short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored A bank of high risk normal mammary epithelial cells will be established To further characterize the mammary epithelial cells in this population of women cell cultures will subsequently be analyzed for their growth and metabolic properties sensitivity to chemopreventive agents steroid receptor characteristics oncogene expression and regulation and genetic changes
Detailed Description:
Women who are at high risk for breast cancer either because of linkage to high risk breast and ovarian cancer families or because of a carcinoma in the opposite breast will be studied Women will have a physical examination and mammography to ensure that no breast abnormalities are present Eligible women will undergo biopsy of the breast to obtain normal breast tissue Short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored A bank of high risk normal mammary epithelial cells will be established To further characterize the mammary epithelial cells in this population of women cell cultures will subsequently be analyzed for their growth and metabolic properties sensitivity to chemopreventive agents steroid receptor characteristics oncogene expression and regulation and genetic changes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 96-C-0026 | None | None | None |