Ignite Creation Date:
2024-05-06 @ 3:57 PM
Last Modification Date:
2024-10-26 @ 2:00 PM
Study NCT ID:
NCT04813003
Status:
COMPLETED
Last Update Posted:
2022-09-23
First Post:
2021-01-18
Brief Title:
How Altered Gut-Brain-Axis Influences Food Choices Part 1
Sponsor:
Lia Bally
Organization:
Insel Gruppe AG University Hospital Bern
Study Overview
Official Title:
How Altered Gut-Brain-Axis Influences Food Choices BrainFood Part 1 Brain Imaging and Computational Modelling
Status:
COMPLETED
Status Verified Date:
2022-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BrainFood
Brief Summary:
Obesity is currently one of the most substantial health burdens Due to the production of marked and sustained weight loss bariatric surgery is an increasingly used therapeutic modality to combat obesity and its comorbidities Surgical rearrangement of the gastrointestinal tract remarkably alters metabolism and hormones acting on neurological and hypothalamic signalling involved in food decision-making and eating behaviour In this context many patients who underwent bariatric surgery self-report changes in appetite satiety and food preferences Furthermore new gut hormone-based eg GLP1-receptor agonist or GLP-1-RA pharmacotherapies which mimic the effect of bariatric surgery show impressive efficacy on weight reduction by modulation of food behaviour However the mechanisms of such functional changes and how they relate to food decision-making remain unknown
In this project the investigators propose a novel approach to unravel the effect of obesity treatments surgical and non-surgical on the neural coding of nutritional attributes and its impact on dietary choices using a combination of brain imaging computational modelling of food behaviour and assessment of eating and food purchase behaviour in daily life
In this project the investigators propose a novel approach to unravel the effect of obesity treatments surgical and non-surgical on the neural coding of nutritional attributes and its impact on dietary choices using a combination of brain imaging computational modelling of food behaviour and assessment of eating and food purchase behaviour in daily life
Detailed Description:
The overall aim of this project is to elucidate the neurobehavioural underpinnings of food behaviour among obese adults and how food behavior is altered by different obesity treatmentsTo this end the study consists of an experimental setting combining neurobehavioural tasks computational modelling and functional brain imaging
The main objective of Part 1 of the BrainFood-project is to elucidate if neural coding and food behaviour differ between obese adults and lean adults The investigators hypothesize that subjective neural processes of nutritional food attributes differ between the obese and control participants showing an unhealthier pattern among obese participants
To this aim the outcomes will be compared between groups surgery group and control group
The main objective of Part 1 of the BrainFood-project is to elucidate if neural coding and food behaviour differ between obese adults and lean adults The investigators hypothesize that subjective neural processes of nutritional food attributes differ between the obese and control participants showing an unhealthier pattern among obese participants
To this aim the outcomes will be compared between groups surgery group and control group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None